KIF21A - kinesin family member 21A Gene

Homo sapiens

Also known as FEOM1; CFEOM1; FEOM3A

Gene ID: 55605 | Gene type: protein coding

About KIF21A

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:39,293,228-39,443,120 (from NCBI)

This gene has 14 transcripts (splice variants), 287 orthologues, 41 paralogues and is associated with 4 phenotypes. Broad expression in brain (RPKM 25.3), kidney (RPKM 9.6) and 22 other tissues.

Summary

This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]

KIF21A Products(7)

mRNA	Protein	Name
NM_001173463.2	NP_001166934.1	kinesin-like protein KIF21A isoform 3
NM_001173464.2	NP_001166935.1	kinesin-like protein KIF21A isoform 1
NM_001173465.2	NP_001166936.1	kinesin-like protein KIF21A isoform 4
NM_001378439.1	NP_001365368.1	kinesin-like protein KIF21A isoform 5
NM_001378440.1	NP_001365369.1	kinesin-like protein KIF21A isoform 6
NM_001378441.1	NP_001365370.1	kinesin-like protein KIF21A isoform 7
NM_017641.4	NP_060111.2	kinesin-like protein KIF21A isoform 2

KIF21A Protein Structure

Kinesin

WD40

0
300
600
900
1200
1500
1674 a.a.

Protein Preferred Names

Protein Names

kinesin-like protein KIF21A

kinesin-like protein KIF2

Related Diseases

Diseases

Alias

Fibrosis Of Extraocular Muscles, Congenital, 1

Fibrosis Of Extraocular Muscles, Congenital, 3b	CFEOM1
Blepharoptosis With Absent Eye Movements	Congenital Fibrosis Of The Extraocular Muscles 1
Congenital Fibrosis Of Extraocular Muscles Type 1	Fibrosis
Ophthalmoplegia, Congenital	Feom1 Locus
Congenital Ophthalmoplegia	Feom1
CFEOM3B	Fibrosis, Extraocular Muscles, Congenital, Type 1
Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles	Cfeom
Feom	Congenital External Ophthalmoplegia
Congenital Fibrosis Syndrome	General Fibrosis Syndrome

Ocular Motility Disease

Ocular Motility Disorders	Abnormality Of Eye Movement
Disorder Of Eye Movements	Eye Movement Disorder
Eye Movement Disorders

Fibrosis Of Extraocular Muscles, Congenital, 2

CFEOM2	Feom2 Locus
Fibrosis Of Extraocular Muscles, Congenital, Autosomal Recessive	Congenital Fibrosis Of The Extraocular Muscles 2
Congenital Fibrosis Of Extraocular Muscles Autosomal Recessive	Exotropic Strabismus Fixus
Feom2	Fibrosis, Extraocular Muscles, Congenital, Type 2

Hypotropia

Paralytic Squint

Paralytic Strabismus

Incomitant Dissociation

Hypertropia

Tukel Syndrome

Cfeom-U	Congenital Fibrosis Of The Extraocular Muscles 4
Fibrosis Of Extraocular Muscles, Congenital, With Ulnar Hand Anomalies	Fibrosis Of Extraocular Muscles, Congenital, 4
Cfeom4	Congenital Extraocular Muscle Fibrosis With Ulnar Hand Anomalies
Congenital Fibrosis Of The Extraocular Muscles

Third Cranial Nerve Disease

Disorder Of Oculomotor Nerve	Oculomotor Nerve Disorder
Oculomotor Nerve Paralysis	Third Cranial Nerve Disorder

Myotonic Cataract

Microphthalmia, Isolated 5

Isolated Microphthalmia 5	MCOP5
Microphthalmia, Posterior, With Retinitis Pigmentosa, Foveoschisis, And Optic Disc Drusen	Microphthalmia-Retinitis Pigmentosa-Foveoschisis-Optic Disc Drusen Syndrome
Posterior Microphthalmia With Retinitis Pigmentosa, Foveoschisis And Optic Disc Drusen	Nanophthalmos-Retinitis Pigmentosa-Foveoschisis-Optic Disc Drusen Syndrome
Microphthalmia, Isolated, 5	Microphthalmia Mfrp-Related
Posterior Microphthalmia With Retinitis Pigmentosa, Foveoschisis And Optic Disk Drusen	Microphthalmia, Isolated, Type 5

Exotropia

Divergent Concomitant Strabismus	Divergent Strabismus
Divergent Squint	External Strabismus
Xt - [Exotropia]

Congenital Ptosis

Congenital Blepharoptosis

Congenital Eyelid Ptosis

Ptosis

Blepharoptosis	Drooping Eyelid
Droopy Eyelid	Ptosis Of Eyelid
Paralysis Of Levator Palpebrae Superioris

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Marcus Gunn Phenomenon

Jaw-Winking Syndrome	Marcus-Gunn Syndrome
Jaw-Winking	Maxillopalpebral Synkinesis
Abnormal Innervation Syndrome Of Eyelid	Jaw-Blinking
Pterygoid-Levator Synkinesis	Familial Marcus Gunn Phenomenon
Marcus Gunn Syndrome	Mandibulo-Palpebral Synkinesis-Ptosis Syndrome
Marcus-Gunn Phenomenon

Kearns-Sayre Syndrome

Ophthalmoplegia	Mitochondrial Cytopathy
KSS	Ophthalmoplegia, Pigmentary Degeneration Of Retina, And Cardiomyopathy
Oculocraniosomatic Syndrome	Chronic Progressive External Ophthalmoplegia With Myopathy
Cpeo With Myopathy	Total Ophthalmoplegia
Ophthalmoplegia-Plus Syndrome	Ophthalmoplegia, Progressive External, With Ragged-Red Fibers
Cpeo With Ragged-Red Fibers	Oculomotor Paralysis
Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication O	Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia Due To Duplication Of Mitochondrial Dna
Proximal Tubulopathy, Diabetes Mellitus And Cerebellar Ataxia	Cpeo With Ragged Red Fibers
Ophthalmoplegia Plus Syndrome	Ophthalmoplegia, Progressive External, With Ragged Red Fibers
Kearns-Sayre Mitochondrial Cytopathy	Mitochondrial Myopathies

Partial Third-Nerve Palsy

Partial Third Nerve Palsy	Third Nerve Palsy With Pupil Sparing
Third Or Oculomotor Nerve Palsy, Partial	Oculomotor Nerve Diseases
Oculomotor Nerve Paralysis

Cranial Nerve Disease

Cranial Nerve Disorder	Disorder Of Cranial Nerve
Cranial Nerve Diseases

Abnormal Retinal Correspondence

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Duane-Radial Ray Syndrome

Okihiro Syndrome	DRRS
Dr Syndrome	Duane Anomaly With Radial Ray Abnormalities And Deafness
Acrorenoocular Syndrome	Acrorenocular Syndrome
Duane Anomaly With Radial Abnormalities And Deafness	Acro-Renal-Ocular Syndrome

Moebius Syndrome

Mobius Syndrome	Moebius Sequence
Oromandibular-Limb Hypogenesis Spectrum	Congenital Facial Diplegia
MBS	Moebius Congenital Oculofacial Paralysis
Absence Or Underdevelopment Of The 6th And 7th Cranial Nerves	Congenital Facial Diplegia Syndrome
Congenital Oculofacial Paralysis	Congenital Ophthalmoplegia And Facial Paresis
Moebius Spectrum	Möbius Sequence
Möbius Syndrome	Mobius Ii Syndrome

Esotropia

Convergence In Manifest Squint	Crossed Eyes
Internal Strabismus	Convergent Concomitant Strabismus
Convergent Squint	Convergent Strabismus
Cross-Eye

Fourth Cranial Nerve Palsy

Fourth Nerve Palsy	Fourth Cranial Nerve Paresis
Fourth Or Trochlear Nerve Palsy	4th Nerve Palsy
Fourth Cranial Nerve Paralysis	Superior Oblique Palsy
Trochlear Nerve Palsy	Trochlear Nerve Paralysis
Trochlear Nerve Weakness	Isolated Trochlear Nerve Palsy
Atrophy Of Fourth Cranial Nerve	Atrophy Of Trochlear Nerve

Rippling Muscle Disease 2

Rippling Muscle Disease	Rmd
Lgmd1c	RMD2
Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1c	Muscular Dystrophy, Limb-Girdle, Type 1c
Muscular Dystrophy, Limb-Girdle, Type 1c, Formerly	Lgmd1c, Formerly
Limb-Girdle Muscular Dystrophy Type 1c	Limb-Girdle Muscular Dystrophy Due To Caveolin-3 Deficiency
Muscular Dystrophy, Limb-Girdle, Type Ic	Rippling Muscle Syndrome
Limb-Girdle Muscular Dystrophy 1c	Dystrophy, Muscular, Limb-Girdle, Type 1c
Disease, Muscle, Rippling, Type 2	Rippling Muscle Disease 1

Optic Nerve Hypoplasia, Bilateral

Optic Nerve Hypoplasia	Bilateral Optic Nerve Hypoplasia
Optic Nerve Hypoplasia, Familial Bilateral	Familial Bilateral Optic Nerve Hypoplasia
Isolated Optic Nerve Hypoplasia/Aplasia	Optic Nerve Aplasia, Bilateral
Onh	BONH
Bilateral Optic Nerve Aplasia	Hypoplasia, Optic Nerve, Bilateral

Amblyopia

Lazy Eye

Keratitis, Hereditary

Keratitis	Autosomal Dominant Keratitis
Hereditary Keratitis	Dominantly Inherited Keratitis
Keratitis Hereditary	KERH

Refractive Error

Refractive Errors

Facial Nerve Disease

Facial Nerve Disorder	Facial Nerve Diseases
Neuropathy Of Facial Nerve	Disorders Of 7th Cranial Nerve
Disorders Of The Seventh Cranial Nerve

Distal Arthrogryposis

Arthrogryposis Multiplex Congenita	Arthrogryposis
Congenital Multiple Arthrogryposis	Congenital Arthromyodysplasia
Fibrous Ankylosis Of Multiple Joints	Guerin-Stern Syndrome
Guérin-Stern Syndrome	Myodystrophia Fetalis Deformans
Otto Syndrome	Rocher-Sheldon Syndrome
Rossi Syndrome	Amc
Multiple Congenital Arthrogryposis	Arthrogryposis Syndrome
Arthrogryposis, Distal	Distal Arthrogryposis Syndrome
Freeman-Sheldon Syndrome	Arthrogryposis, Distal, Type 2b
Congenital Multiplex Arthrogryposis	Amyoplasia Congenita
Congenital Amyoplasia	Amc - [Arthrogryposis Multiplex Congenita]

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07274	KIF21A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIF21A	MGD	MGI:109188
Canis familiaris	KIF21A	VGNC	VGNC:42396
Bos taurus	KIF21A	VGNC	VGNC:30595
Rattus norvegicus	KIF21A	RGD	RGD:1305126
Macaca mulatta	KIF21A	VGNC	VGNC:73861
Felis catus	KIF21A	VGNC	VGNC:63112