PKN1 - protein kinase N1 Gene

Homo sapiens

Also known as DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA

Gene ID: 5585 | Gene type: protein coding

About PKN1

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,433,306-14,471,859 (from NCBI)

This gene has 15 transcripts (splice variants), 290 orthologues and 9 paralogues. Ubiquitous expression in spleen (RPKM 39.4), fat (RPKM 30.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by Phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate Insulin signals to the actin Cytoskeleton. The proteolytic activation of this kinase by Caspase-3 or related proteases during Apoptosis suggests its role in signal transduction related to Apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PKN1 Products(2)

mRNA	Protein	Name
NM_002741.5	NP_002732.3	serine/threonine-protein kinase N1 isoform 2
NM_213560.3	NP_998725.1	serine/threonine-protein kinase N1 isoform 1

PKN1 Protein Structure

HR1

Pkinase

Pkinase_C

0
200
400
600
800
942 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase N1

protease-activated kinase 1

Related Diseases

Diseases

Alias

Mevalonic Aciduria

Mevalonate Kinase Deficiency	Mevalonicaciduria
Hyperimmunoglobulin D With Periodic Fever	MEVA
Complete Mevalonate Kinase Deficiency	Mva
Hyperimmunoglobulinemia D	Hyper Igd Syndrome
Periodic Fever, Dutch Type	Mkd
Aciduria, Mevalonic	Deficiency Of Mevalonate Kinase

Malignant Acrospiroma

Eccrine Ductal Carcinoma	Hidradenocarcinoma
Anaplastic Syringoma	Eccrine Ductal Carcinoma Of Skin
Clear Cell Eccrine Carcinoma	Malignant Clear Cell Acrospiroma
Malignant Nodular/Clear Cell Hidradenoma	Primary Mucoepidermoid Cutaneous Carcinoma
Sweat Gland Adenocarcinoma

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Bubonic Plague

Black Death	Plague, Bubonic
Plague, Septicemic	Pestis Bubonica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145899	PKN1/2-IN-1	Inhibitor	98.48%	Unkown
HY-RS10606	PKN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PKN1	VGNC	VGNC:69063
Macaca mulatta	PKN1	VGNC	VGNC:76014
Bos taurus	PKN1	VGNC	VGNC:32945
Canis familiaris	PKN1	VGNC	VGNC:44611
Rattus norvegicus	PKN1	RGD	RGD:69308
Mus musculus	PKN1	MGD	MGI:108022
Others	PKN1	NCBI

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