2. Gene
  3. Bace2 - beta-site APP-cleaving enzyme 2 Gene

Bace2 - beta-site APP-cleaving enzyme 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ARP1; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; 1110059C24Rik

Gene ID: 56175 | Gene type: protein coding

About Bace2

Chromosome 16: 97,157,942-97,244,136 forward strand.GRCm39:CM001009.3

This gene has 4 transcripts (splice variants), 215 orthologues, 8 paralogues and is associated with 10 phenotypes. Biased expression in stomach adult (RPKM 52.5), colon adult (RPKM 18.7) and 8 other tissues.

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein undergoes proteolytic processing to generate an active endopeptidase Enzyme. This transmembrane protease catalyzes the proteolysis of amyloid precursor protein to produce amyloid beta peptide. Mice lacking the encoded product exhibit increased pancreatic beta cell mass and improved glucose tolerance due to increased Insulin secretion. [provided by RefSeq, Jul 2016]

Bace2 Products(1)

mRNA Protein Name
NM_019517.5 NP_062390.3 beta-secretase 2 preproprotein

Bace2 Protein Structure

beta_secretase_like

beta_secretase_like: cd05473 (84 - 445)

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  • 514 a.a.
Protein Preferred Names Protein Names

beta-secretase 2

aspartyl protease 1

beta-site amyloid precursor protein cleaving enzyme 2

memapsin-1

membrane-associated aspartic protease 1

theta-secretase

Recombinant Bace2 Proteins

Cat. No. Product Name Accession Purity
HY-P75588 BACE2 Protein, Mouse (HEK293, His) Q9JL18 (A20-P462) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16759 Verubecestat Inhibitor 99.56% Phase 3
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136742 BACE2-IN-1 Inhibitor 99.34% Unkown
HY-161359 BACE1-IN-14 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bace2 NCBI NCBI:25825