PSG1 - pregnancy specific beta-1-glycoprotein 1 Gene

Homo sapiens

Also known as SP1; B1G1; PBG1; CD66f; PSBG1; PSG95; PSGGA; DHFRP2; PSBG-1; PSGIIA; FL-NCA-1/2; PS-beta-C/D; PS-beta-G-1

Gene ID: 5669 | Gene type: protein coding

About PSG1

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,866,464-42,879,713 (from NCBI)

This gene has 11 transcripts (splice variants), 627 orthologues and 24 paralogues. Restricted expression toward placenta (RPKM 224.3).

Summary

The human placenta is a multihormonal endocrine organ that produces Hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]

PSG1 Products(5)

mRNA	Protein	Name
NM_001184825.2	NP_001171754.1	pregnancy-specific beta-1-glycoprotein 1 isoform 2 precursor
NM_001184826.2	NP_001171755.1	pregnancy-specific beta-1-glycoprotein 1 isoform 3 precursor
NM_001297773.2	NP_001284702.1	pregnancy-specific beta-1-glycoprotein 1 isoform 4 precursor
NM_001330524.2	NP_001317453.1	pregnancy-specific beta-1-glycoprotein 1 isoform 5 precursor
NM_006905.3	NP_008836.2	pregnancy-specific beta-1-glycoprotein 1 isoform 1 precursor

PSG1 Protein Structure

V-set

Ig_2

0
100
200
300
419 a.a.

Protein Preferred Names

Protein Names

pregnancy-specific beta-1-glycoprotein 1

CD66 antigen-like family member F

Recombinant PSG1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72486	PSG1 Protein, Human (HEK293, His)	P11464/NP_001171754.1 (Q35-P419)	≥95%
HY-P75986	PSG1 Protein, Human (HEK293, Fc)	P11464 (M1-P419)	≥95%
HY-P75987	PSG1 Protein, Human (419a.a, HEK293, His)	P11464 (M1-P419)	≥95%

Related Diseases

Diseases

Alias

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole	Gestational Trophoblastic Disease
Complete Hydatidiform Mole	Hydm
HYDM1	Chm
Molar Pregnancy	Hydatidiform Mole, Complete
Hydatid Mole	Complete Molar Pregnancy
Mole, Hydatidiform, Recurrent, Type 1	Gestational Trophoblastic Neoplasms
Hydatidiform Mole, Recurrent, 2	Classical Hydatidiform Mole

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Ectopic Pregnancy

Eccyesis	Pregnancy Ectopic
Pregnancy, Ectopic	Ectopic Pregnancies
Extrauterine Gestation Or Pregnancy	Extrauterine Pregnancy
Ep - [Ectopic Pregnancy]	Ectopic Mole
Aborted Ectopic Pregnancy	Ruptured Ectopic Pregnancy