INTS2 - integrator complex subunit 2 Gene

Homo sapiens

Also known as INT2; KIAA1287

Gene ID: 57508 | Gene type: protein coding

About INTS2

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:61,865,367-61,927,982 (from NCBI)

This gene has 10 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in testis (RPKM 3.6), lymph node (RPKM 3.3) and 25 other tissues.

Summary

INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]

INTS2 Products(3)

mRNA	Protein	Name
NM_001330417.2	NP_001317346.2	integrator complex subunit 2 isoform 2
NM_001351695.2	NP_001338624.2	integrator complex subunit 2 isoform 2
NM_020748.4	NP_065799.2	integrator complex subunit 2 isoform 1

INTS2 Protein Structure

INTS2

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1204 a.a.

Protein Preferred Names

Protein Names

integrator complex subunit 2

Related Diseases

Diseases

Alias

Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 4

PEOA4	Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 4
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 4	Chronic Progressive External Ophthalmoplegia
Progressive External Ophthalmoplegia, Autosomal Dominant 4	Autosomal Dominant Progressive External Ophthalmoplegia 4
Cpeo	Graefe Disease
Mitochondrial Ocular Myopathy	Ocular Myopathy Of Von Graefe-Fuchs
Progressive External Ophthalmoplegia Autosomal Dominant 4	Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 4
Kearns-Sayre Syndrome

Multiple Benign Circumferential Skin Creases On Limbs

Ccsf	Circumferential Skin Creases, Kunze Type
Congenital Circumferential Skin Folds	Kunze-Riehm Syndrome
Kunze Riehm Syndrome	Michelin Tire Baby Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148202	Influenza antiviral conjugate-1	Inhibitor	/	Unkown
HY-RS06854	INTS2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	INTS2	VGNC	VGNC:73681
Felis catus	INTS2	VGNC	VGNC:62943
Mus musculus	INTS2	MGD	MGI:1917672
Canis familiaris	INTS2	VGNC	VGNC:42051
Bos taurus	INTS2	VGNC	VGNC:30228
Rattus norvegicus	INTS2	RGD	RGD:1305547

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