1. Gene
  2. LRRC7 - leucine rich repeat containing 7 Gene

LRRC7 - leucine rich repeat containing 7 Gene

Homo sapiens

Also known as DENSIN

Gene ID: 57554 | Gene type: protein coding

About LRRC7

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:69,567,922-70,144,364 (from NCBI)

This gene has 14 transcripts (splice variants), 208 orthologues and 31 paralogues. Biased expression in brain (RPKM 2.3), testis (RPKM 0.6) and 2 other tissues.

Summary

Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of neuron projection development; and receptor clustering. Located in several cellular components, including centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LRRC7 Products(10)

mRNA Protein Name
NM_001330635.3 NP_001317564.1 leucine-rich repeat-containing protein 7 isoform 2
NM_001350216.3 NP_001337145.1 leucine-rich repeat-containing protein 7 isoform 3
NM_001366836.3 NP_001353765.1 leucine-rich repeat-containing protein 7 isoform 4
NM_001366837.3 NP_001353766.1 leucine-rich repeat-containing protein 7 isoform 5
NM_001366838.3 NP_001353767.1 leucine-rich repeat-containing protein 7 isoform 6
NM_001366839.3 NP_001353768.1 leucine-rich repeat-containing protein 7 isoform 7
NM_001366840.1 NP_001353769.1 leucine-rich repeat-containing protein 7 isoform 8
NM_001366841.1 NP_001353770.1 leucine-rich repeat-containing protein 7 isoform 9
NM_001366842.1 NP_001353771.1 leucine-rich repeat-containing protein 7 isoform 10
NM_001370785.2 NP_001357714.1 leucine-rich repeat-containing protein 7 isoform 11

LRRC7 Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (93 - 114)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (162 - 200)

LRR_8

LRR_8: Leucine rich repeat (208 - 265)

LRR_4

LRR_4: Leucine Rich repeats (2 copies) (345 - 383)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1453 - 1532)

  • 0
  • 300
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  • 900
  • 1200
  • 1537 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat-containing protein 7

densin-180

Related Diseases

Diseases Alias
Psoriasis 9

PSORS9

Psoriasis 9, Susceptibility To

Psoriasis Susceptibility 9

Cri-Du-Chat Syndrome

5p Deletion Syndrome

5p Partial Monosomy Syndrome

Monosomy 5p

Cat Cry Syndrome

Chromosome 5p Deletion Syndrome

Cri Du Chat Syndrome

5p- Syndrome

5p Minus Syndrome

Chromosome 5p- Syndrome

Chromosome 5 Short Arm Deletion Syndrome

Chromosome 5p Deletion

Deletion 5p

Cri Du Chat

5p Partial Deletion Syndrome

Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Hypomelanosis Of Ito

Incontinentia Pigmenti Achromians

Nevus Of Ito

Ipa

Ito Hypomelanosis

Ito

Pigmentation Disorders

HMI

Incontinentia Pigmenti, Type I, Formerly

Ip1, Formerly

Bloch-Siemans Syndrome

Incontinentia Pigmenti Achromians Syndrome

Ito'S Nevus

Incontinentia Pigmenti Type 1

Nevi Of Ito

Nevus Fuscocaeruleus Acromiodeltoideus

Bloch Sulzberger Syndrome

Skin Pigmentation Disorder

Trichorhinophalangeal Syndrome, Type Ii

Langer-Giedion Syndrome

Lgs

Trichorhinophalangeal Syndrome Type Ii

Trichorhinophalangeal Syndrome Type 2

TRPS2

Monosomy 8q24.1

Chromosome 8q24.1 Deletion Syndrome

Deletion 8q24.1

Giedion-Langer Syndrome

Trichorhinophalangeal Dysplasia Type Ii

Langer Giedion Syndrome

Trps 2

Tricho-Rhino-Phalangeal Syndrome Type Ii

Trichorhinophalangeal Syndrome With Exostosis

Trps Ii

Tricho-Rhino-Phalangeal Syndrome 2

8q24.1 Microdeletion Syndrome

8q24.1 Deletion Syndrome

Galloway-Mowat Syndrome

Galloway Mowat Syndrome

Galloway Syndrome

Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

Microcephaly Nephrosis Syndrome

Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

Nephrosis Neuronal Dysmigration Syndrome

Microcephaly-Hiatus Hernia-Nephrotic Syndrome

Nephrosis-Neuronal Dysmigration Syndrome

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LRRC7 RGD RGD:708527
Canis familiaris LRRC7 VGNC VGNC:54044
Mus musculus LRRC7 MGD MGI:2676665
Felis catus LRRC7 VGNC VGNC:107575
Macaca mulatta LRRC7 VGNC VGNC:100002
Bos taurus LRRC7 VGNC VGNC:55251