2. Gene
  3. DPP10 - dipeptidyl peptidase like 10 Gene

DPP10 - dipeptidyl peptidase like 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DPL2; DPPY; DPRP3; DPRP-3

Gene ID: 57628 | Gene type: protein coding

About DPP10

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:114,442,641-115,845,780 (from NCBI)

This gene has 13 transcripts (splice variants), 272 orthologues and 6 paralogues. Biased expression in brain (RPKM 7.5), adrenal (RPKM 2.9) and 2 other tissues.

Summary

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

DPP10 Products(18)

mRNA Protein Name
NM_001004360.5 NP_001004360.3 inactive dipeptidyl peptidase 10 isoform short
NM_001178034.1 NP_001171505.1 inactive dipeptidyl peptidase 10 isoform c
NM_001178036.3 NP_001171507.2 inactive dipeptidyl peptidase 10 isoform a
NM_001178037.3 NP_001171508.2 inactive dipeptidyl peptidase 10 isoform b
NM_001321905.3 NP_001308834.2 inactive dipeptidyl peptidase 10 isoform d
NM_001321906.2 NP_001308835.2 inactive dipeptidyl peptidase 10 isoform short
NM_001321907.3 NP_001308836.2 inactive dipeptidyl peptidase 10 isoform e
NM_001321908.3 NP_001308837.2 inactive dipeptidyl peptidase 10 isoform f
NM_001321909.3 NP_001308838.2 inactive dipeptidyl peptidase 10 isoform g
NM_001321910.3 NP_001308839.2 inactive dipeptidyl peptidase 10 isoform a
NM_001321911.3 NP_001308840.2 inactive dipeptidyl peptidase 10 isoform a
NM_001321912.3 NP_001308841.2 inactive dipeptidyl peptidase 10 isoform h
NM_001321913.3 NP_001308842.2 inactive dipeptidyl peptidase 10 isoform i
NM_001321914.2 NP_001308843.2 inactive dipeptidyl peptidase 10 isoform i
NM_001399849.1 NP_001386778.1 inactive dipeptidyl peptidase 10 isoform a
NM_001399850.1 NP_001386779.1 inactive dipeptidyl peptidase 10 isoform i
NM_001399851.1 NP_001386780.1 inactive dipeptidyl peptidase 10 isoform j
NM_020868.6 NP_065919.3 inactive dipeptidyl peptidase 10 isoform long

DPP10 Protein Structure

DPPIV_N

DPPIV_N: Dipeptidyl peptidase IV (DPP IV) N-terminal region (133 - 499)

Peptidase_S9

Peptidase_S9: Prolyl oligopeptidase family (581 - 783)

  • 0
  • 200
  • 400
  • 600
  • 796 a.a.
Protein Preferred Names Protein Names

inactive dipeptidyl peptidase 10

DPP X

Recombinant DPP10 Proteins

Cat. No. Product Name Accession Purity
HY-P75281 DPP10 Protein, Human (HEK293, His) Q8N608 (L56-E796) ≥95%

Related Diseases

Diseases Alias
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Near-Fatal Asthma
Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03961 DPP10 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DPP10 VGNC VGNC:61602
Bos taurus DPP10 VGNC VGNC:28186
Mus musculus DPP10 MGD MGI:2442409
Canis familiaris DPP10 VGNC VGNC:40072
Rattus norvegicus DPP10 RGD RGD:1306427
Macaca mulatta DPP10 VGNC VGNC:71873
Others DPP10 NCBI