DHX37 - DEAH-box helicase 37 Gene

Homo sapiens

Also known as Dhr1; DDX37; SRXY11; NEDBAVC

Gene ID: 57647 | Gene type: protein coding

About DHX37

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:124,946,826-124,989,131 (from NCBI)

This gene has 6 transcripts (splice variants), 195 orthologues, 18 paralogues and is associated with 6 phenotypes. Ubiquitous expression in bone marrow (RPKM 4.6), lymph node (RPKM 4.2) and 25 other tissues.

Summary

This gene encodes a DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. [provided by RefSeq, Jul 2008]

DHX37 Products(1)

mRNA	Protein	Name
NM_032656.4	NP_116045.2	probable ATP-dependent RNA helicase DHX37

DHX37 Protein Structure

DEAD

Helicase_C

HA2

OB_NTP_bind

0
200
400
600
800
1000
1157 a.a.

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DHX37

DEAD/DEAH box helicase DDX37

Related Diseases

Diseases

Alias

46,Xy Sex Reversal 11

Testicular Regression Syndrome	Trs
SRXY11	Testicular Regression, Embryonic
Xy Gonadal Agenesis/Dysgenesis Syndrome	Anorchia, Familial
46, Xy Sex Reversal 11	Etrs
Embryonic Testicular Regression Syndrome	Vanishing Testes Syndrome
Vanishing Testis Syndrome	Xy Gonadal Agenesis Syndrome

Neurodevelopmental Disorder With Brain Anomalies And With Or Without Vertebral Or Cardiac Anomalies

NEDBAVC

Anorchia

Testicular Agenesis	Bilateral Anorchia
Absence Of Testes	Congenital Absence Of Testes
Empty Scrotum	Absent Testicle

46,Xy Partial Gonadal Dysgenesis

46,Xy Pgd

46,Xy Partial Testicular Dysgenesis

46,Xy Sex Reversal

Swyer Syndrome	Pure Gonadal Dysgenesis 46,Xy
Gonadal Dysgenesis, Xy Female Type	Gonadal Dysgenesis, 46,Xy
46,Xy Cgd	46,Xy Complete Gonadal Dysgenesis
46,Xy Pure Gonadal Dysgenesis	46 Xy Gonadal Dysgenesis
46, Xy Cgd	46, Xy Complete Gonadal Dysgenesis
46, Xy Pure Gonadal Dysgenesis	Xy Pure Gonadal Dysgenesis
Female With 46,Xy Karyotype	Xy Females

Coloboma Of Optic Nerve

Morning Glory Disc Anomaly	Coloboma Of Optic Disc
Morning Glory Syndrome	Ectasic Coloboma
Coloboma Of Optic Papilla	Congenital Coloboma Of The Optic Nerve
Optic Nerve Coloboma	Optic Nerve Head Pits, Bilateral Congenital
Volubilis Syndrome	COLON
Coloboma Of Optic Disc, Unspecified Eye	Congenital Coloboma Of Optic Disc
Optic Disk Coloboma

Polymicrogyria

Pmg

Neuronal Migration Disorders

Abnormality Of Neuronal Migration	Malformations Of Cortical Development, Group Ii
Neuronal Dysmigration Syndromes

Developmental And Epileptic Encephalopathy 23

DEE23	Epileptic Encephalopathy, Early Infantile, 23
Eiee23	Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Epilepsy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome	Developmental And Epileptic Encephalopathy, 23
Early Infantile Epileptic Encephalopathy 23

Gonadal Dysgenesis

Gonadal Dysgenesis Syndrome

Turner Syndrome

Immunodeficiency 40

Dock2 Deficiency	IMD40
Immunodeficiency, Type 40

Adams-Oliver Syndrome

Adams Oliver Syndrome	Aos
Congenital Scalp Defects With Distal Limb Reduction Anomalies	Aplasia Cutis Congenita With Terminal Transverse Limb Defects
Congenital Scalp Defects With Distal Limb Anomalies	Limb, Scalp And Skull Defects
Limb Scalp And Skull Defects	Absence Defect Of Limbs, Scalp, And Skull

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03756	DHX37 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DHX37	VGNC	VGNC:71639
Bos taurus	DHX37	VGNC	VGNC:28055
Felis catus	DHX37	VGNC	VGNC:61482
Rattus norvegicus	DHX37	RGD	RGD:1306837
Mus musculus	DHX37	MGD	MGI:3028576
Canis familiaris	DHX37	VGNC	VGNC:39947

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