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  2. PTPRJ - protein tyrosine phosphatase receptor type J Gene

PTPRJ - protein tyrosine phosphatase receptor type J Gene

Homo sapiens

Also known as DEP1; SCC1; CD148; HPTPeta; R-PTP-J; HPTP eta; R-PTP-ETA

Gene ID: 5795 | Gene type: protein coding

About PTPRJ

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,980,559-48,170,839 (from NCBI)

This gene has 7 transcripts (splice variants), 214 orthologues, 35 paralogues and is associated with 1 phenotype. Broad expression in thyroid (RPKM 11.4), appendix (RPKM 10.8) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTPRJ Products(2)

mRNA Protein Name
NM_001098503.2 NP_001091973.1 receptor-type tyrosine-protein phosphatase eta isoform 2 precursor
NM_002843.4 NP_002834.3 receptor-type tyrosine-protein phosphatase eta isoform 1 precursor

PTPRJ Protein Structure

fn3

fn3: Fibronectin type III domain (120 - 187)

fn3

fn3: Fibronectin type III domain (369 - 437)

fn3

fn3: Fibronectin type III domain (541 - 606)

fn3

fn3: Fibronectin type III domain (626 - 704)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (1065 - 1296)

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  • 1337 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase eta

CD148 antigen

Recombinant PTPRJ Proteins

Cat. No. Product Name Accession Purity
HY-P74200 DEP-1/CD148 Protein, Human (341a.a, His) Q12913-1 (R997-A1337) ≥95%

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Interstitial Keratitis
Cogan Syndrome

Cogan'S Syndrome

Diffuse Interstitual Keratitis

Cogans Syndrome

Oculovestibuloauditory Syndrome

Cd45 Deficiency
Thrombosis

Thrombosis Of Blood Vessel

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Methotrexate-Associated Lymphoproliferation
Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1

Persistent Hyperinsulinemic Hypoglycemia Of Infancy

Familial Hyperinsulinemic Hypoglycemia 1

Congenital Hyperinsulinism

Phhi

Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency

Hypoglycemia, Hyperinsulinemic, Of Infancy

Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia

Nesidioblastosis Of Pancreas

Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis

Hyperinsulinism, Congenital

Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency

Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form

Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency

Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency

Hypoglycemia, Hyperinsulinemic, Familial, Type 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus PTPRJ VGNC VGNC:106883
Felis catus PTPRJ VGNC VGNC:69175
Rattus norvegicus PTPRJ RGD RGD:3454
Macaca mulatta PTPRJ VGNC VGNC:76618
Canis familiaris PTPRJ VGNC VGNC:45190
Mus musculus PTPRJ MGD MGI:104574
Others PTPRJ NCBI