RAB2A - RAB2A, member RAS oncogene family Gene

Homo sapiens

Also known as LHX; RAB2

Gene ID: 5862 | Gene type: protein coding

About RAB2A

Cytogenetic location: 8q12.1-q12.2 Genomic coordinates (GRCh38): 8:60,516,910-60,623,644 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 68 paralogues. Ubiquitous expression in brain (RPKM 44.0), thyroid (RPKM 43.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

RAB2A Products(2)

mRNA	Protein	Name
NM_001242644.1	NP_001229573.1	ras-related protein Rab-2A isoform b
NM_002865.3	NP_002856.1	ras-related protein Rab-2A isoform a

RAB2A Protein Structure

Ras

0
100
200
212 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-2A

RAB2, member RAS oncogene family

Related Diseases

Diseases

Alias

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Lipoblastoma

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Chronic Salpingo-Oophoritis

Chronic Salpingitis And Oophoritis

Chronic Salpingitis/Oophoritis

Warburg Micro Syndrome 3

WARBM3

Micro Syndrome 3

Warburg Micro Syndrome 2

WARBM2

Micro Syndrome 2

Smith-Mccort Dysplasia 1

Smith-Mccort Dysplasia	SMC1
Smc	Smith Mccort Dysplasia
Smith-Mccort Dwarfism

Warburg Micro Syndrome 4

WARBM4

Micro Syndrome 4

Salpingo-Oophoritis

Tubo-Ovarian Inflammatory Disease	Salpingitis/Oophoritis
Suppurative Salpingo Oophoritis	Tubo-Ovarian Inflammation
Tubo-Ovarian Inflammatory Disorder	Purulent Salpingo Oophoritis
Septic Salpingo Oophoritis	Salpingo-Ovaritis
Inflammation Oviduct	Ruptured Salpingo Oophoritis
Pyosalpinx Rupture

Dyggve-Melchior-Clausen Disease

Dyggve-Melchior-Clausen Syndrome	DMC
Dmc Disease	Pseudo-Morquio Disease Type I
Dmc Syndrome

Duane Retraction Syndrome

Stilling-Turk-Duane Syndrome	Duane'S Syndrome
Duane Syndrome	Isolated Duane Retraction Syndrome
Co-Contractive Retraction Syndrome	Duane Anomaly, Isolated
Ocular Retraction Syndrome	Drs
Durs

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124306	ML-099	Activator	99.37%	Unkown
HY-RS11541	RAB2A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAB2A	VGNC	VGNC:33637
Canis familiaris	RAB2A	VGNC	VGNC:45271
Macaca mulatta	RAB2A	VGNC	VGNC:81529
Felis catus	RAB2A	VGNC	VGNC:97587
Mus musculus	RAB2A	MGD	MGI:1928750
Rattus norvegicus	RAB2A	RGD	RGD:68323
Others	RAB2A	NCBI

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