RAD23A - RAD23 homolog A, nucleotide excision repair protein Gene

Homo sapiens

Also known as HR23A; HHR23A

Gene ID: 5886 | Gene type: protein coding

About RAD23A

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,945,862-12,953,642 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 50.3), heart (RPKM 47.4) and 25 other tissues.

Summary

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the Proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

RAD23A Products(3)

mRNA	Protein	Name
NM_001270362.2	NP_001257291.1	UV excision repair protein RAD23 homolog A isoform 2
NM_001270363.2	NP_001257292.1	UV excision repair protein RAD23 homolog A isoform 3
NM_005053.4	NP_005044.1	UV excision repair protein RAD23 homolog A isoform 1

RAD23A Protein Structure

ubiquitin

UBA

XPC-binding

UBA

0
100
200
300
363 a.a.

Protein Preferred Names

Protein Names

UV excision repair protein RAD23 homolog A

RAD23, yeast homolog, A

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Group C	XPC
Xpcc	Xeroderma Pigmentosum Iii
Xp3	Xeroderma Pigmentosum Group C
Xp Group C	Xp, Group C
Xeroderma Pigmentosum, Type 3	Xeroderma Pigmentosum Complementation Group C
XP-C

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Brain Sarcoma

Sarcoma Of The Brain

Hyperinsulinemic Hypoglycemia, Familial, 2

Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
Familial Hyperinsulinism	Congenital Hyperinsulinism
HHF2	Nesidioblastosis
Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia	Familial Hyperinsulinemic Hypoglycemia 2
Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency	Chi
Congenital Isolated Hyperinsulinism	Hyperinsulinemic Hypoglycemia, Persistent
Hyperinsulinism, Neonatal	Hyperinsulinism, Congenital
Hyperinsulinism, Familial	Hyperinsulinemic Hypoglycemia Familial
Hyperinsulinism Congenital	Hyperinsulinism Familial With Pancreatic Nesidioblastosis
Hypoglycemia Hyperinsulinemic Of Infancy	Nesidioblastosis Of Pancreas
Hyperinsulinemic Hypoglycemia Familial 2	Hyperinsulinemia Hypoglycemia Of Infancy
Infancy Hyperinsulinemia Hypoglycemia	Neonatal Hyperinsulinism
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Persistent Hyperinsulinemic Hypoglycemia
Phhi Hypoglycemia	Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency	Dominant Katp Hyperinsulinism Due To Kir6.2 Deficiency
Diazoxide-Resistant Focal Hyperinsulinism Due To Kir6.2 Deficiency	Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency, Diazoxide-Resistant Focal Form
Fhi	Familial Hyperinsulinemic Hypoglycemia
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency	Hypoglycemia, Hyperinsulinemic, Familial, Type 2
Hi-C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11600	RAD23A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAD23A	VGNC	VGNC:76643
Felis catus	RAD23A	VGNC	VGNC:69213
Mus musculus	RAD23A	MGD	MGI:105126
Rattus norvegicus	RAD23A	RGD	RGD:1309899
Canis familiaris	RAD23A	VGNC	VGNC:45315
Bos taurus	RAD23A	VGNC	VGNC:33682

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