2. Gene
  3. Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

Nr1h4 - nuclear receptor subfamily 1, group H, member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Fxr

Gene ID: 60351 | Gene type: protein coding

About Nr1h4

Primary_assembly 7: 23,846,122-23,942,047 reverse strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 388 orthologues, 19 paralogues and is associated with 37 phenotypes. Biased expression in Liver (RPKM 265.5) and Kidney (RPKM 198.2).

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bile acid receptor activity; and chenodeoxycholic acid binding activity. Contributes to double-stranded DNA binding activity. Involved in several processes, including lipid homeostasis; liver development; and negative regulation of biosynthetic process. Located in nucleus. Part of receptor complex. Used to study extrahepatic cholestasis; intrahepatic cholestasis; and portal hypertension. Biomarker of bile duct disease (multiple); liver disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; and premature menopause. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h4 Products(1)

mRNA Protein Name
NM_021745.1 NP_068513.1 bile acid receptor

Nr1h4 Protein Structure

NR_DBD_FXR

NR_DBD_FXR: cd06962 (163 - 250)

NR_LBD_Fxr

NR_LBD_Fxr: cd06936 (291 - 510)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 516 a.a.
Protein Preferred Names Protein Names

bile acid receptor

RXR-interacting protein 14

farnesoid X-activated receptor

farnesol receptor HRR-1

retinoid X receptor-interacting protein 14

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125996 NR1H4 activator 1 Agonist / Unkown
HY-RS09531 NR1H4 Human Pre-designed siRNA Set A / Unkown
HY-RS09532 Nr1h4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09533 Nr1h4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nr1h4 NCBI NCBI:9971