2. Gene
  3. Gsk3a - glycogen synthase kinase 3 alpha Gene

Gsk3a - glycogen synthase kinase 3 alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 2700086H06Rik

Gene ID: 606496 | Gene type: protein coding

About Gsk3a

Chromosome 7: 24,927,683-24,937,276 reverse strand.GRCm39:CM001000.3

This gene has 3 transcripts (splice variants), 260 orthologues, 1 paralogue and is associated with 42 phenotypes. Ubiquitous expression in thymus adult (RPKM 12.9), duodenum adult (RPKM 75.3) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of G protein-coupled receptor signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to lithium ion; positive regulation of protein phosphorylation; and protein phosphorylation. Predicted to be located in microtubule. Predicted to be active in axon; cytosol; and nucleus. Is expressed in several structures, including central nervous system; cranium; early conceptus; tongue; and upper jaw. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]

Gsk3a Products(1)

mRNA Protein Name
NM_001031667.1 NP_001026837.1 glycogen synthase kinase-3 alpha

Gsk3a Protein Structure

STKc_GSK3

STKc_GSK3: cd14137 (113 - 406)

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  • 490 a.a.
Protein Preferred Names Protein Names

glycogen synthase kinase-3 alpha

GSK-3 alpha

serine/threonine-protein kinase GSK3A

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.00% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-RS05862 GSK3A Human Pre-designed siRNA Set A / Unkown
HY-RS05863 Gsk3a Mouse Pre-designed siRNA Set A / Unkown
HY-RS05864 Gsk3a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsk3a NCBI NCBI:2931