RREB1 - ras responsive element binding protein 1 Gene

Homo sapiens

Also known as HNT; FINB; LZ321; Zep-1; RREB-1

Gene ID: 6239 | Gene type: protein coding

About RREB1

Cytogenetic location: 6p24.3 Genomic coordinates (GRCh38): 6:7,107,743-7,251,980 (from NCBI)

This gene has 9 transcripts (splice variants), 216 orthologues, 14 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 4.1), colon (RPKM 3.6) and 25 other tissues.

Summary

The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the Calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of Calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

RREB1 Products(4)

mRNA	Protein	Name
NM_001003698.4	NP_001003698.1	ras-responsive element-binding protein 1 isoform 2
NM_001003699.4	NP_001003699.1	ras-responsive element-binding protein 1 isoform 1
NM_001003700.2	NP_001003700.1	ras-responsive element-binding protein 1 isoform 3
NM_001168344.2	NP_001161816.1	ras-responsive element-binding protein 1 isoform 2

RREB1 Protein Structure

zf-C2H2_4

zf-H2C2_2

zf-C2H2_4

zf-H2C2_2

zf-C2H2

zf-H2C2_2

0
300
600
900
1200
1500
1687 a.a.

Protein Preferred Names

Protein Names

ras-responsive element-binding protein 1

DNA-binding protein

Related Diseases

Diseases

Alias

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Scrotum Melanoma

Melanoma Of Scrotum

Spitzoid Melanoma

Atypical Spitz Nevus

Chromosome 6pter-P24 Deletion Syndrome

6p Subtelomeric Deletion Syndrome	6p25 Microdeletion Syndrome
Distal Monosomy 6p	Distal Deletion 6p
Monosomy 6p25

Tumoral Calcinosis, Normophosphatemic, Familial

Normophosphatemic Familial Tumoral Calcinosis	NFTC
Tumoral Calcinosis, Familial, Normophosphatemic	Calcinosis, Tumoral, With Normophosphatemia
Familial Normophosphatemic Tumoral Calcinosis	Tumoral Calcinosis With Normophosphatemia

Scrotum Neoplasm

Malignant Tumour Of Scrotum	Malignant Scrotal Neoplasm
Malignant Tumor Of Scrotum	Neoplasm Of Scrotum
Scrotal Ca	Scrotal Tumor
Scrotum Cancer	Cancer Of Scrotum
Malignant Neoplasm Of Scrotum	Scrotal Cancer
Malignant Scrotal Tumour	Malignant Neoplasm Of Skin Of Scrotum
Primary Malignant Neoplasm Of Scrotum

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma	Familial Medullary Thyroid Carcinoma
MTC	Medullary Thyroid Cancer
Fmtc	Mtc1
Thyroid Cancer, Medullary	Thyroid Carcinoma, Medullary
Familial Mtc	Thyroid Carcinoma Medullary
Carcinoma, Thyroid, Medullary, Familial	Medullary Carcinoma Of Thyroid
Medullary Carcinoma With Amyloid Stroma, Unspecified Site	Medullary Carcinoma With Amyloid Stroma Of Thyroid

Vulvar Melanoma

Malignant Melanoma Of Vulva

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12283	RREB1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RREB1	RGD	RGD:1310904
Felis catus	RREB1	VGNC	VGNC:64773
Macaca mulatta	RREB1	VGNC	VGNC:76939
Bos taurus	RREB1	VGNC	VGNC:34162
Canis familiaris	RREB1	VGNC	VGNC:45758
Mus musculus	RREB1	MGD	MGI:2443664

Name
Email *

	Sorry, but the email address you supplied was invalid.