MS4A6A - membrane spanning 4-domains A6A Gene

Homo sapiens

Also known as CDA01; MS4A6; 4SPAN3; CD20L3; MST090; MSTP090; 4SPAN3.2

Gene ID: 64231 | Gene type: protein coding

About MS4A6A

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,171,607-60,184,666 (from NCBI)

This gene has 21 transcripts (splice variants), 362 orthologues and 16 paralogues. Broad expression in lymph node (RPKM 27.7), spleen (RPKM 26.2) and 22 other tissues.

Summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]

MS4A6A Products(5)

mRNA	Protein	Name
NM_001247999.2	NP_001234928.1	membrane-spanning 4-domains subfamily A member 6A isoform 4
NM_001330275.1	NP_001317204.1	membrane-spanning 4-domains subfamily A member 6A isoform 5
NM_022349.4	NP_071744.2	membrane-spanning 4-domains subfamily A member 6A isoform 2
NM_152851.2	NP_690590.1	membrane-spanning 4-domains subfamily A member 6A isoform 3
NM_152852.3	NP_690591.1	membrane-spanning 4-domains subfamily A member 6A isoform 1

MS4A6A Protein Structure

CD20

0
100
200
248 a.a.

Protein Preferred Names

Protein Names

membrane-spanning 4-domains subfamily A member 6A

CD20 antigen-like 3

Related Diseases

Diseases

Alias

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08704	MS4A6A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MS4A6A	RGD	RGD:1305800
Macaca mulatta	MS4A6A	VGNC	VGNC:101361

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