2. Gene
  3. ATG3 - autophagy related 3 Gene

ATG3 - autophagy related 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APG3; APG3L; hApg3; PC3-96; APG3-LIKE

Gene ID: 64422 | Gene type: protein coding

About ATG3

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,532,510-112,561,962 (from NCBI)

This gene has 9 transcripts (splice variants) and 220 orthologues. Ubiquitous expression in testis (RPKM 24.5), bone marrow (RPKM 17.6) and 25 other tissues.

Summary

This gene encodes a ubiquitin-like-conjugating Enzyme and is a component of ubiquitination-like systems involved in Autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of Autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

ATG3 Products(2)

mRNA Protein Name
NM_001278712.2 NP_001265641.1 ubiquitin-like-conjugating enzyme ATG3 isoform 2
NM_022488.5 NP_071933.2 ubiquitin-like-conjugating enzyme ATG3 isoform 1

ATG3 Protein Structure

Autophagy_N

Autophagy_N: Autophagocytosis associated protein (Atg3), N-terminal domain (8 - 150)

Autophagy_act_C

Autophagy_act_C: Autophagocytosis associated protein, active-site domain (203 - 265)

Autophagy_C

Autophagy_C: Autophagocytosis associated protein C-terminal (286 - 310)

  • 0
  • 100
  • 200
  • 314 a.a.
Protein Preferred Names Protein Names

ubiquitin-like-conjugating enzyme ATG3

APG3 autophagy 3-like

Recombinant ATG3 Proteins

Cat. No. Product Name Accession Purity
HY-P7617 ATG3 Protein, Human Q9NT62 (M1-M314) ≥95%

Related Diseases

Diseases Alias
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis

Acanthamoeba Encephalitis

Acanthamoeba Granulomatous Encephalitis

Granulomatous Amebic Encephalitis Due To Acanthamoeba
Primary Amebic Meningoencephalitis

Pam

Naegleria Fowleri Infection

Meningoencephalitis Caused By Naegleria Fowleri

Primary Amoebic Meningoencephalitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156966 ATG12-ATG3 inhibitor 1 Inhibitor 99.31% Unkown
HY-RS01147 ATG3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ATG3 VGNC VGNC:103660
Rattus norvegicus ATG3 RGD RGD:708464
Mus musculus ATG3 MGD MGI:1915091
Bos taurus ATG3 VGNC VGNC:26256
Macaca mulatta ATG3 VGNC VGNC:70105
Felis catus ATG3 VGNC VGNC:102599
Others ATG3 NCBI