CREB3L2 - cAMP responsive element binding protein 3 like 2 Gene

Homo sapiens

Also known as BBF2H7

Gene ID: 64764 | Gene type: protein coding

About CREB3L2

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:137,874,979-138,002,086 (from NCBI)

This gene has 6 transcripts (splice variants), 219 orthologues, 9 paralogues and is associated with 82 phenotypes. Ubiquitous expression in thyroid (RPKM 36.0), placenta (RPKM 17.4) and 24 other tissues.

Summary

This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

CREB3L2 Products(3)

mRNA	Protein	Name
NM_001253775.2	NP_001240704.1	cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 2
NM_001318246.2	NP_001305175.1	cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 3
NM_194071.4	NP_919047.2	cyclic AMP-responsive element-binding protein 3-like protein 2 isoform 1

CREB3L2 Protein Structure

bZIP_1

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-responsive element-binding protein 3-like protein 2

B-ZIB transcription factor

Related Diseases

Diseases

Alias

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Adult Fibrosarcoma

Spindle Cell Liposarcoma

Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Isolated Growth Hormone Deficiency, Type Ii

Ighd Ii	Isolated Growth Hormone Deficiency Type Ii
IGHD2	Growth Hormone Deficiency, Isolated, Type Ii
Congenital Ighd Type Ii	Congenital Isolated Gh Deficiency Type Ii
Congenital Isolated Growth Hormone Deficiency Type Ii	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency Autosomal Dominant
Growth Hormone Deficiency, Isolated, Autosomal Dominant	Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency, Autosomal Dominant
Autosomal Dominant Isolated Growth Hormone Deficiency	Autosomal Dominant Pituitary Dwarfism Due To Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 2	Growth Hormone Deficiency, Isolated Autosomal Dominant
Growth Hormone Deficiency, Isolated, 2	Growth Hormone Deficiency Isolated Autosomal Dominant

Perineurioma

Soft Tissue Perineurioma

Pseudosarcomatous Fibromatosis

Nodular Fasciitis	Pseudosarcomatous Fasciitis
Fasciitis - Nodular	Fasciitis Nodular

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Ossifying Fibromyxoid Tumor

Ossifying Fibromyxoid Tumour

Ossifying Fibromyxoma

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Keratosis Follicularis Spinulosa Decalvans

Kfsd	Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi
Keratosis Follicularis Spinulosa Decalvans, X-Linked	Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03151	CREB3L2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CREB3L2	VGNC	VGNC:71497
Felis catus	CREB3L2	VGNC	VGNC:61167
Rattus norvegicus	CREB3L2	RGD	RGD:1306040
Bos taurus	CREB3L2	VGNC	VGNC:27695
Mus musculus	CREB3L2	MGD	MGI:2442695
Canis familiaris	CREB3L2	VGNC	VGNC:39598

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