SIAH2 - siah E3 ubiquitin protein ligase 2 Gene

Homo sapiens

Also known as hSiah2

Gene ID: 6478 | Gene type: protein coding

About SIAH2

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:150,741,125-150,763,169 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 42.6), placenta (RPKM 22.5) and 24 other tissues.

Summary

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]

SIAH2 Products(1)

mRNA	Protein	Name
NM_005067.7	NP_005058.3	E3 ubiquitin-protein ligase SIAH2

SIAH2 Protein Structure

Sina

0
100
200
300
324 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase SIAH2

RING-type E3 ubiquitin transferase SIAH2

Related Diseases

Diseases

Alias

Dyskeratosis Congenita, Autosomal Dominant 3

DKCA3	Autosomal Dominant Dyskeratosis Congenita 3
Dyskeratosis Congenita, Autosomal Dominant, 3	Dyskeratosis Congenita, Autosomal Dominant, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12892	SIAH2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SIAH2	VGNC	VGNC:102843
Macaca mulatta	SIAH2	VGNC	VGNC:77215
Bos taurus	SIAH2	VGNC	VGNC:34614
Mus musculus	SIAH2	MGD	MGI:108062
Rattus norvegicus	SIAH2	RGD	RGD:620778

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