GINS3 - GINS complex subunit 3 Gene

Homo sapiens

Also known as PSF3

Gene ID: 64785 | Gene type: protein coding

About GINS3

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,392,471-58,406,147 (from NCBI)

This gene has 10 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in lymph node (RPKM 4.0), testis (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GINS3 Products(3)

mRNA	Protein	Name
NM_001126129.2	NP_001119601.1	DNA replication complex GINS protein PSF3 isoform a
NM_001126130.2	NP_001119602.1	DNA replication complex GINS protein PSF3 isoform c
NM_022770.4	NP_073607.2	DNA replication complex GINS protein PSF3 isoform b

GINS3 Protein Structure

Sld5

0
100
200
216 a.a.

Protein Preferred Names

Protein Names

DNA replication complex GINS protein PSF3

GINS complex subunit 3 (Psf3 homolog)

Related Diseases

Diseases

Alias

Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05432	GINS3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GINS3	VGNC	VGNC:62555
Rattus norvegicus	GINS3	RGD	RGD:1308153
Mus musculus	GINS3	MGD	MGI:1926083
Bos taurus	GINS3	VGNC	VGNC:29362
Canis familiaris	GINS3	VGNC	VGNC:41222
Macaca mulatta	GINS3	VGNC	VGNC:73014

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