TBC1D15 - TBC1 domain family member 15 Gene

Homo sapiens

Also known as RAB7-GAP

Gene ID: 64786 | Gene type: protein coding

About TBC1D15

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,839,759-71,924,313 (from NCBI)

This gene has 17 transcripts (splice variants), 218 orthologues and 45 paralogues. Ubiquitous expression in thyroid (RPKM 10.9), adrenal (RPKM 9.8) and 25 other tissues.

Summary

This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

TBC1D15 Products(10)

mRNA	Protein	Name
NM_001146213.3	NP_001139685.2	TBC1 domain family member 15 isoform 3
NM_001146214.3	NP_001139686.2	TBC1 domain family member 15 isoform 2
NM_001385848.1	NP_001372777.1	TBC1 domain family member 15 isoform 4
NM_001385849.1	NP_001372778.1	TBC1 domain family member 15 isoform 5
NM_001385850.1	NP_001372779.1	TBC1 domain family member 15 isoform 6
NM_001385851.1	NP_001372780.1	TBC1 domain family member 15 isoform 7
NM_001385852.1	NP_001372781.1	TBC1 domain family member 15 isoform 8
NM_001385853.1	NP_001372782.1	TBC1 domain family member 15 isoform 9
NM_001385854.1	NP_001372783.1	TBC1 domain family member 15 isoform 10
NM_022771.6	NP_073608.4	TBC1 domain family member 15 isoform 1

TBC1D15 Protein Structure

DUF3548

RabGAP-TBC

0
200
400
600
691 a.a.

Protein Preferred Names

Protein Names

TBC1 domain family member 15

GAP for RAB7

Related Diseases

Diseases

Alias

Warburg Micro Syndrome 4

WARBM4

Micro Syndrome 4

Charcot-Marie-Tooth Disease, Axonal, Type 2b

Charcot-Marie-Tooth Disease Type 2b	CMT2B
Hmsn Iib	Hmsn2b
Charcot-Marie-Tooth Disease, Type 2b	Hereditary Motor And Sensory Neuropathy Iib
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2b	Charcot-Marie-Tooth Neuropathy Type 2b
Charcot-Marie-Tooth Disease, Autosomal Dominant, Type 2b	Charcot-Marie-Tooth Neuropathy, Type 2b
Hereditary Motor And Sensory Nueropathy Iib	Cmt 2b
Charcot Marie Tooth Disease Type 2b	Charcot-Marie-Tooth Disease, Neuronal, Type 2b
Hereditary Motor And Sensory Neuropathy 2 B	Peripheral Sensory Neuropathy, Autosomal Dominant
Charcot-Marie-Tooth Disease 2b	Charcot-Marie-Tooth Disease Axonal Type 2b
Charcot-Marie-Tooth Disease Neuronal Type 2b	Peripheral Sensory Neuropathy Autosomal Dominant
Psn

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14232	TBC1D15 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TBC1D15	MGD	MGI:1913937
Macaca mulatta	TBC1D15	VGNC	VGNC:78215
Felis catus	TBC1D15	VGNC	VGNC:65974
Rattus norvegicus	TBC1D15	RGD	RGD:1307920
Bos taurus	TBC1D15	VGNC	VGNC:35629
Canis familiaris	TBC1D15	VGNC	VGNC:47134

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