MRPS6 - mitochondrial ribosomal protein S6 Gene

Homo sapiens

Also known as S6mt; RPMS6; MRP-S6; C21orf101

Gene ID: 64968 | Gene type: protein coding

About MRPS6

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:34,073,578-34,143,030 (from NCBI)

This gene has 5 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in kidney (RPKM 62.4), thyroid (RPKM 41.2) and 24 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]

MRPS6 Products(1)

mRNA	Protein	Name
NM_032476.4	NP_115865.1	28S ribosomal protein S6, mitochondrial

MRPS6 Protein Structure

Ribosomal_S6

0
100
125 a.a.

Protein Preferred Names

Protein Names

28S ribosomal protein S6, mitochondrial

mitochondrial small ribosomal subunit protein bS6m

Related Diseases

Diseases

Alias

Jervell And Lange-Nielsen Syndrome 1

Jervell And Lange-Nielsen Syndrome	Jervell-Lange Nielsen Syndrome
Prolonged Qt Interval In Ekg And Sudden Death	Cardioauditory Syndrome Of Jervell And Lange-Nielsen
Surdo-Cardiac Syndrome	JLNS1
Deafness, Congenital, And Functional Heart Disease	Jlns
Long Qt Interval-Deafness Syndrome	Jervell And Lange-Nielson Syndrome
Jervell Lange-Nielsen Syndrome	Autosomal Recessive Long Qt Syndrome
Cardio-Auditory-Syncope Syndrome	Long Qt Interval-Hearing Loss Syndrome
Congenital Deafness And Functional Heart Disease	Long Qt Interval-Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08689	MRPS6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MRPS6	RGD	RGD:2322928
Macaca mulatta	MRPS6	VGNC	VGNC:108423
Mus musculus	MRPS6	MGD	MGI:2153111
Bos taurus	MRPS6	VGNC	VGNC:31676

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