FUNDC2 - FUN14 domain containing 2 Gene

Homo sapiens

Also known as DC44; HCC3; HCBP6; PD03104

Gene ID: 65991 | Gene type: protein coding

About FUNDC2

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,026,844-155,060,304 (from NCBI)

This gene has 7 transcripts (splice variants), 167 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 26.0), ovary (RPKM 19.3) and 25 other tissues.

Summary

Predicted to be involved in Autophagy of mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

FUNDC2 Products(1)

mRNA	Protein	Name
NM_023934.4	NP_076423.2	FUN14 domain-containing protein 2

FUNDC2 Protein Structure

FUN14

0
100
189 a.a.

Protein Preferred Names

Protein Names

FUN14 domain-containing protein 2

HCC-3

Related Diseases

Diseases

Alias

Factor Viii Deficiency

Autosomal Hemophilia A	Hemophilia A
Autosomal Factor Viii Deficiency	Classic Hemophilia A
Congenital Factor Viii Disorder	Subhemophilia
Factor 8 Deficiency, Congenital	Factor Viii

Hemophilia A

Factor Viii Deficiency	Haemophilia A
Mild Hemophilia A	HEMA
Hemophilia, Classic	Classic Hemophilia
Factor 8 Deficiency	Severe Hemophilia A
Classical Hemophilia	Hem A
Hemophilia A, Congenital	Mild Congenital F8 Deficiency
Mild Congenital Factor Viii Deficiency	Severe Congenital F8 Deficiency
Severe Congenital Factor Viii Deficiency	Moderate Hemophilia A
Moderate Congenital F8 Deficiency	Moderate Congenital Factor Viii Deficiency
Bleeding Disorder In Hemophilia A Carriers	Congenital F8 Deficiency
Congenital Fviii Deficiency	Congenital Factor Viii Deficiency
Mild Hereditary Factor Viii Deficiency Disease	Severe Hereditary Factor Viii Deficiency Disease
Ahg - [Antihaemophilic Globulin] Deficiency	Ahg - [Antihaemophilic Globulin] Deficiency Disease
Congenital Factor Viii Disorder	Sex-Linked Factor Viii Deficiency
Antihaemophilic Globulin Deficiency	Classic Haemophilia
Familial Haemophilia	Haemophilia
Hereditary Haemophilia	Subhaemophilia
Haemophilia Nos

X-Linked Intellectual Disability-Cardiomegaly-Congestive Heart Failure Syndrome

Mental Retardation, X-Linked, Syndromic 32

Mrxs32

Non-Syndromic X-Linked Intellectual Disability 72

Mrx72

Hepatitis C Virus

Hepatitis C Virus, Susceptibility To	Hepatitis C Virus Infection, Response To Therapy Of
Hcv	Hcv, Susceptibility To
Hepatitis C Virus, Resistance To	Hepatitis C Virus, Response To Therapy Of
Resistance To Hepatitis C Virus

Syndromic X-Linked Intellectual Disability Shashi Type

Mental Retardation, X-Linked, Syndromic 11, Shashi Type	Mrxs11
Shashi X-Linked Mental Retardation Syndrome	Smrxs
Syndromic X-Linked Intellectual Disability Type 11	X-Linked Mental Retardation Shashi Type
Mental Retardation, X-Linked, Syndromic 11

Moyamoya Disease 1

Moyamoya Disease	Spontaneous Occlusion Of The Circle Of Willis
Mymy	Progressive Intracranial Arterial Occlusion
Moyamoya Syndrome	MYMY1
Cerebrovascular Moyamoya Disease	Moya-Moya Disease
Progressive Intracranial Occlusive Arteropathy	Idiopathic Moyamoya Disease

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05146	FUNDC2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FUNDC2	RGD	RGD:1560916
Bos taurus	FUNDC2	VGNC	VGNC:29144
Mus musculus	FUNDC2	MGD	MGI:1914641
Macaca mulatta	FUNDC2	VGNC	VGNC:81185
Felis catus	FUNDC2	VGNC	VGNC:62389
Canis familiaris	FUNDC2	VGNC	VGNC:41008

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