SNRPA1 - small nuclear ribonucleoprotein polypeptide A' Gene

Homo sapiens

Also known as Lea1; U2A'

Gene ID: 6627 | Gene type: protein coding

About SNRPA1

Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:101,281,510-101,295,248 (from NCBI)

This gene has 15 transcripts (splice variants), 231 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 26.0), testis (RPKM 22.8) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and spermatogenesis. Located in nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Implicated in connective tissue disease. [provided by Alliance of Genome Resources, Apr 2022]

SNRPA1 Products(1)

mRNA	Protein	Name
NM_003090.4	NP_003081.2	U2 small nuclear ribonucleoprotein A'

SNRPA1 Protein Structure

LRR_9

0
100
200
255 a.a.

Protein Preferred Names

Protein Names

U2 small nuclear ribonucleoprotein A'

U2 small nuclear ribonucleoprotein polypeptide A'

Related Diseases

Diseases

Alias

Primary Optic Atrophy

Galloway-Mowat Syndrome 1

Galloway Syndrome	Nephrosis-Neuronal Dysmigration Syndrome
Nephrosis-Microcephaly Syndrome	Camos
Scar5	GAMOS1
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Microcephaly, Hiatal Hernia And Nephrotic Syndrome
Cerebellar Ataxia With Mental Retardation, Optic Atrophy, And Skin Abnormalities	Spinocerebellar Ataxia, Autosomal Recessive 5, Formerly
Scar5, Formerly	Spinocerebellar Ataxia Autosomal Recessive 5
Cerebellar Ataxia With Intellectual Disability Optic Atrophy And Skin Abnormalities	Camos Syndrome
Cerebellar Ataxia-Intellectual Disability-Optic Atrophy-Skin Abnormalities Syndrome	Galloway-Mowat Syndrome
Spinocerebellar Ataxia, Autosomal Recessive, 5	Galloway Mowat Syndrome
Spinocerebellar Ataxia, Autosomal Recessive 5

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13501	SNRPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SNRPA1	RGD	RGD:2320494
Felis catus	SNRPA1	VGNC	VGNC:80840
Canis familiaris	SNRPA1	VGNC	VGNC:46610
Mus musculus	SNRPA1	MGD	MGI:1916231
Macaca mulatta	SNRPA1	VGNC	VGNC:77675
Bos taurus	SNRPA1	VGNC	VGNC:35075

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