XCL2 - X-C motif chemokine ligand 2 Gene

Homo sapiens

Also known as SCM1B; SCYC2; SCM-1b

Gene ID: 6846 | Gene type: protein coding

About XCL2

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,540,768-168,543,997 (from NCBI)

This gene has 1 transcript (splice variant), 117 orthologues and 25 paralogues. Broad expression in spleen (RPKM 4.0), bone marrow (RPKM 3.8) and 18 other tissues.

Summary

Predicted to enable CCR Chemokine Receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of T cell chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

XCL2 Products(1)

mRNA	Protein	Name
NM_003175.4	NP_003166.1	cytokine SCM-1 beta precursor

XCL2 Protein Structure

IL8

0
100
114 a.a.

Protein Preferred Names

Protein Names

cytokine SCM-1 beta

XC chemokine ligand 2

Recombinant XCL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74461	XCL2/SCM-1 beta Protein, Human (sf9, His)	Q9UBD3 (M1-G114)	≥95%

Related Diseases

Diseases

Alias

Recombinase Activating Gene 1 Deficiency

Combined Cellular And Humoral Immune Defects With Granulomas

Combined Immunodeficiency With Skin Granulomas	CCHIDG
Cid Due To Rag 1/2 Deficiency	Combined Immunodeficiency Due To Rag 1/2 Deficiency
Combined Immunodeficiency With Granulomatosis	CHIDG
Immune Defects, Combined Cellular And Humoral With Granulomas

Photokeratitis

Immunodeficiency 44

IMD44

Cataract 44

CTRCT44	Total Early-Onset Cataract
Cataract 44 And Hypotrichosis	Cataract And Hypotrichosis
Cataract, Type 44

Bardet-Biedl Syndrome 1

BBS1	Bardet-Biedl Syndrome 1, Modifier Of
Bardet-Biedl Syndrome	BBS
Bardet-Biedl Syndrome, Type 1	Laurence-Moon-Bardet-Biedl Syndrome

Iminoglycinuria

Iminoglycinuria, Digenic

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15867	XCL2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	XCL2	MGD	MGI:104593
Rattus norvegicus	XCL2	NCBI