USP4 - ubiquitin specific peptidase 4 Gene

Homo sapiens

Also known as UNP; Unph

Gene ID: 7375 | Gene type: protein coding

About USP4

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,277,144-49,340,053 (from NCBI)

This gene has 14 transcripts (splice variants), 140 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 15.1), bone marrow (RPKM 14.6) and 25 other tissues.

Summary

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

USP4 Products(3)

mRNA	Protein	Name
NM_001251877.2	NP_001238806.1	ubiquitin carboxyl-terminal hydrolase 4 isoform c
NM_003363.4	NP_003354.2	ubiquitin carboxyl-terminal hydrolase 4 isoform a
NM_199443.3	NP_955475.1	ubiquitin carboxyl-terminal hydrolase 4 isoform b

USP4 Protein Structure

DUSP

Ubiquitin_3

UCH

0
200
400
600
800
963 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 4

deubiquitinating enzyme 4

Related Diseases

Diseases

Alias

Oculopharyngeal Muscular Dystrophy

OPMD	Muscular Dystrophy, Oculopharyngeal
Dystrophy, Oculopharyngeal Muscular	Oculopharyngeal Dystrophy
Progressive Muscular Dystrophy, Oculopharyngeal Type	Muscular Dystrophy Oculopharyngeal
Dystrophy, Muscular, Oculopharyngeal

Trichorhinophalangeal Syndrome, Type I

Trichorhinophalangeal Dysplasia Type I	TRPS1
Trichorhinophalangeal Syndrome Type I	Trps I
Trichorhinophalangeal Syndrome Type 1	Type I Trichorhinophalangeal Syndrome
Giedion Syndrome	Trp Syndrome
Tricho-Rhino-Phalangeal Syndrome 1	Trichorhinophalangeal Syndrome, Type Iii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13814	PR-619		99.38%	Unkown
HY-103435	Vialinin A	Inhibitor	≥99.0%	Unkown
HY-RS15551	USP4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	USP4	VGNC	VGNC:66886
Bos taurus	USP4	VGNC	VGNC:36729
Macaca mulatta	USP4	VGNC	VGNC:78416
Rattus norvegicus	USP4	RGD	RGD:1587387
Mus musculus	USP4	MGD	MGI:98905
Canis familiaris	USP4	VGNC	VGNC:48195
Others	USP4	NCBI

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