VDAC2 - voltage dependent anion channel 2 Gene

Homo sapiens

Also known as POR

Gene ID: 7417 | Gene type: protein coding

About VDAC2

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:75,210,170-75,231,448 (from NCBI)

This gene has 14 transcripts (splice variants), 237 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 81.3), esophagus (RPKM 66.2) and 25 other tissues.

Summary

This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

VDAC2 Products(8)

mRNA	Protein	Name
NM_001184783.3	NP_001171712.1	voltage-dependent anion-selective channel protein 2 isoform 1
NM_001184823.2	NP_001171752.1	voltage-dependent anion-selective channel protein 2 isoform 2
NM_001324087.2	NP_001311016.1	voltage-dependent anion-selective channel protein 2 isoform 3
NM_001324088.2	NP_001311017.1	voltage-dependent anion-selective channel protein 2 isoform 2
NM_001324089.2	NP_001311018.1	voltage-dependent anion-selective channel protein 2 isoform 3
NM_001324090.2	NP_001311019.1	voltage-dependent anion-selective channel protein 2 isoform 3
NM_001391963.1	NP_001378892.1	voltage-dependent anion-selective channel protein 2 isoform 2
NM_003375.5	NP_003366.2	voltage-dependent anion-selective channel protein 2 isoform 2

VDAC2 Protein Structure

Porin_3

0
100
200
294 a.a.

Protein Preferred Names

Protein Names

voltage-dependent anion-selective channel protein 2

epididymis secretory sperm binding protein

Related Diseases

Diseases

Alias

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15763	Erastin		99.76%	Unkown
HY-128777	WEHI-9625	Inhibitor	99.46%	Unkown
HY-RS15630	VDAC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	VDAC2	MGD	MGI:106915
Rattus norvegicus	VDAC2	RGD	RGD:621576
Bos taurus	VDAC2	VGNC	VGNC:36783
Macaca mulatta	VDAC2	VGNC	VGNC:78763
Canis familiaris	VDAC2	VGNC	VGNC:48247
Felis catus	VDAC2	VGNC	VGNC:97682

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