2. Gene
  3. ZFX - zinc finger protein X-linked Gene

ZFX - zinc finger protein X-linked Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ZNF926

Gene ID: 7543 | Gene type: protein coding

About ZFX

Cytogenetic location: Xp22.11 Genomic coordinates (GRCh38): X:24,148,982-24,216,255 (from NCBI)

This gene has 11 transcripts (splice variants), 107 orthologues and 38 paralogues. Ubiquitous expression in endometrium (RPKM 5.2), thyroid (RPKM 4.9) and 25 other tissues.

Summary

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

ZFX Products(6)

mRNA Protein Name
NM_001178084.2 NP_001171555.1 zinc finger X-chromosomal protein isoform 1
NM_001178085.1 NP_001171556.1 zinc finger X-chromosomal protein isoform 1
NM_001178086.2 NP_001171557.1 zinc finger X-chromosomal protein isoform 2
NM_001178095.2 NP_001171566.1 zinc finger X-chromosomal protein isoform 3
NM_001330327.2 NP_001317256.1 zinc finger X-chromosomal protein isoform 4
NM_003410.4 NP_003401.2 zinc finger X-chromosomal protein isoform 1

ZFX Protein Structure

Zfx_Zfy_act

Zfx_Zfy_act: Zfx / Zfy transcription activation region (69 - 410)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (425 - 447)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (456 - 478)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (489 - 510)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (519 - 542)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (563 - 584)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (590 - 615)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (647 - 672)

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (690 - 714)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (734 - 757)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (776 - 798)

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  • 805 a.a.
Protein Preferred Names Protein Names

zinc finger X-chromosomal protein

X-linked zinc finger protein

Related Diseases

Diseases Alias
46,Xx Sex Reversal

46,Xx Testicular Disorder Of Sex Development

46,Xx Testicular Dsd

De La Chapelle Syndrome

Srxx

Xx, Male Syndrome

46, Xx Testicular Disorders Of Sex Development
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16053 ZFX Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZFX RGD RGD:1562664
Mus musculus ZFX MGD MGI:99211