2. Gene
  3. CA1 - carbonic anhydrase 1 Gene

CA1 - carbonic anhydrase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAB; CA-I; Car1; HEL-S-11

Gene ID: 759 | Gene type: protein coding

About CA1

Cytogenetic location: 8q21.2 Genomic coordinates (GRCh38): 8:85,327,608-85,378,113 (from NCBI)

This gene has 25 transcripts (splice variants), 286 orthologues and 14 paralogues. Biased expression in bone marrow (RPKM 551.6) and colon (RPKM 322.2).

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This CA1 gene is closely linked to the CA2 and CA3 genes on chromosome 8. It encodes a cytosolic protein that is found at the highest level in erythrocytes. Allelic variants of this gene have been described in some populations. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]

CA1 Products(7)

mRNA Protein Name
NM_001128830.4 NP_001122302.1 carbonic anhydrase 1 isoform a
NM_001128829.4 NP_001122301.1 carbonic anhydrase 1 isoform a
NM_001738.5 NP_001729.1 carbonic anhydrase 1 isoform a
NM_001128831.4 NP_001122303.1 carbonic anhydrase 1 isoform a
NM_001164830.2 NP_001158302.1 carbonic anhydrase 1 isoform a
NM_001291968.2 NP_001278897.1 carbonic anhydrase 1 isoform c
NM_001291967.2 NP_001278896.1 carbonic anhydrase 1 isoform b

CA1 Protein Structure

Carb_anhydrase

Carb_anhydrase: Eukaryotic-type carbonic anhydrase (6 - 261)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

carbonic anhydrase 1

carbonate dehydratase I

carbonic anhydrase B

carbonic anhydrase I

cyanamide hydratase CA1

epididymis secretory protein Li 11

epididymis secretory sperm binding protein

Recombinant CA1 Proteins

Cat. No. Product Name Accession Purity
HY-P7718 Carbonic Anhydrase 1 Protein, Human (His) P00915 (A2-F261) ≥95%
HY-P71997 CA1, Human (His) P00915 (A2-F261) ≥95%

Related Diseases

Diseases Alias
Cataract 3, Multiple Types

Cataract 3 Multiple Types

CTRCT3

Cca2

Cataract, Congenital, Cerulean Type, 2

Cataract 3, Multiple Types, With Or Without Microcornea

Cataract 3 Multiple Types With Or Without Microcornea

Congenital Cerulean Type Cataract 2

Congenital Cataract Blue Dot Type 2

Congenital Cataract Cerulean Type 2

Cspc

Sutural Cataract With Punctate And Cerulean Opacities
Alzheimer Disease 11

Ad11

Alzheimer'S Disease 11

Alzheimer Disease, Familial, 11

Alzheimer Disease-11

Alzheimer'S Disease 11, Late Onset
Intracranial Hypertension, Idiopathic

Pseudotumor Cerebri

Benign Intracranial Hypertension

Idiopathic Intracranial Hypertension

Iih

Benign Intracran. Hypt.
Osteopetrosis, Autosomal Recessive 3

Osteopetrosis With Renal Tubular Acidosis

Marble Brain Disease

OPTB3

Guibaud-Vainsel Syndrome

Carbonic Anhydrase Ii Deficiency

Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis

Autosomal Recessive Osteopetrosis 3

Carbonic Anhydrase 2 Deficiency

Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis

Osteopetrosis Autosomal Recessive 3

Autosomal Recessive Osteopetrosis Type 3

Guibaud Vainsel Syndrome

Mixed Rta

Mixed Renal Tubular Acidosis

Renal Tubular Acidosis Type 3

Carbonic Anhydrase Ii Deficiency Syndrome

Carbonic Anhydrase Ii Variant

Osteopetrosis, Autosomal Recessive, Type 3

Carbonic Anhydrase 2
Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1
Transient Global Amnesia

Amnesia, Transient Global
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0764 Bucladesine sodium 99.48% Yes
HY-B1424 Benzthiazide Inhibitor 99.70% Unkown
HY-10932 Aniracetam Modulator 99.89% Unkown
HY-116790 (-)-Penbutolol Antagonist / Unkown
Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-I1070 D-Isoleucine ≥98.0% Unkown
HY-N5130 Effusol Inhibitor 99.83% Unkown
HY-100606 l-Pindolol 99.89% Unkown
HY-P3914 Cecropin A (1-7)-Melittin A (2-9) Inhibitor 98.99% Unkown
HY-126967 1-Palmitoyl lysophosphatidic acid ≥99.0% Unkown
HY-106784A (E)-Ajoene / Unkown
HY-16147 Combretastatin A1 phosphate 98.00% Yes
HY-P1387 β-Amyloid (1-40) (rat) Inducer 95.13% Unkown
HY-100843 L-AP6 / Unkown
HY-103502 CGP7930 Modulator / Unkown
HY-116431 I-BOP Agonist / Unkown
HY-139145 Etbicyphat Antagonist ≥98.0% Unkown
HY-139145S Etbicyphat-13C3 / Unkown
HY-P4397 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin / Unkown
HY-RS01762 CA1 Human Pre-designed siRNA Set A / Unkown
HY-116143 MAGL-IN-12 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CA1 VGNC VGNC:38604
Felis catus CA1 VGNC VGNC:60239
Rattus norvegicus CA1 RGD RGD:1309780
Macaca mulatta CA1 VGNC VGNC:83986
Mus musculus CA1 MGD MGI:88268
Macaca fascicularis CA1 NCBI NCBI:102126955
Susscrofa domestica CA1 NCBI
Others CA1 NCBI