2. Gene
  3. COLEC11 - collectin subfamily member 11 Gene

COLEC11 - collectin subfamily member 11 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 3MC2; CLK1; CL-11; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb

Gene ID: 78989 | Gene type: protein coding

About COLEC11

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:3,595,112-3,644,644 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues, 4 paralogues and is associated with 3 phenotypes. Biased expression in gall bladder (RPKM 20.2), liver (RPKM 13.5) and 9 other tissues.

Summary

This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on Microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

COLEC11 Products(10)

mRNA Protein Name
NM_001255982.2 NP_001242911.1 collectin-11 isoform c precursor
NM_001255983.2 NP_001242912.1 collectin-11 isoform d precursor
NM_001255984.2 NP_001242913.1 collectin-11 isoform e precursor
NM_001255985.1 NP_001242914.1 collectin-11 isoform f precursor
NM_001255986.1 NP_001242915.1 collectin-11 isoform g
NM_001255987.1 NP_001242916.1 collectin-11 isoform h
NM_001255988.1 NP_001242917.1 collectin-11 isoform i
NM_001255989.1 NP_001242918.1 collectin-11 isoform j
NM_024027.5 NP_076932.1 collectin-11 isoform a precursor
NM_199235.3 NP_954705.1 collectin-11 isoform b

COLEC11 Protein Structure

Collagen

Collagen: Collagen triple helix repeat (20 copies) (41 - 92)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (62 - 111)

Lectin_C

Lectin_C: Lectin C-type domain (160 - 266)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

collectin-11

Collectin K1

Recombinant COLEC11 Proteins

Cat. No. Product Name Accession Purity
HY-P70100 Collectin-11/CL-K1 Protein, Human (HEK293, His) Q9BWP8 (Q26-M271) ≥95%

Related Diseases

Diseases Alias
3mc Syndrome 2

3MC2

Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia

Oculo-Skeletal-Abdominal Syndrome

Osa Syndrome

Carnevale Syndrome

Carnevale Syndrome, Formerly

Carnevale Krajewska Fischetto Syndrome

3mc Syndrome, Type 2
3mc Syndrome

Craniofacial-Ulnar-Renal Syndrome

Malpuech Facial Clefting Syndrome

Oculopalatoskeletal Syndrome

Carnevale Syndrome

Michels Syndrome

Malpuech-Michels-Mingarelli-Carnevale Syndrome

Carnevale-Krajewska-Fischetto Syndrome

Craniosynostosis With Lid Anomalies

Malpuech Syndrome

Mingarelli Syndrome

Oculo-Skeletal-Abdominal Syndrome

Osa Syndrome

Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia

Ptosis-Strabismus-Rectus Abdominis Diastasis
Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder
3mc Syndrome 1

Oculopalatoskeletal Syndrome

3MC1

Craniosynostosis With Lid Anomalies

Michels Syndrome, Formerly

Michels Syndrome

3mc Syndrome, Type 1
Blepharophimosis
Properdin Deficiency, X-Linked

Properdin Deficiency

PFD

CFPD

Properdin P Factor Deficiency

Complement Factor Properdin Deficiency

X-Linked Properdin Deficiency

Properdin Deficiency, Type I

Properdin Deficiency, Type 1

Properdin Deficiency Disease
Van Maldergem Syndrome 1

Cerebrofacioarticular Syndrome

VMLDS1

Van Maldergem Syndrome

Cerebro-Facio-Articular Syndrome

Van Maldergem Wetzburger Verloes Syndrome
Radioulnar Synostosis

Radio-Ulnar Synostosis Type 1
Coffin-Siris Syndrome 9

Mrd27

CSS9

Mental Retardation, Autosomal Dominant 27

Autosomal Dominant Mental Retardation 27

Autosomal Dominant Non-Syndromic Intellectual Disability 27

Coffin-Siris Syndrome, Type 9
Craniosynostosis

Premature Closure Of Cranial Sutures

Craniostenosis

Craniosynostosis Syndrome

Cso

Craniosynostoses

Congenital Ossification Of Cranial Sutures

Congenital Ossification Of Sutures Of Skull

Craniostosis

Imperfect Fusion Of Skull

Congenital Imperfect Closure Skull

Imperfect Closure Skull

Premature Closure Cranium Sutures

Deficiency Of Craniofacial Axis
Urinary Schistosomiasis

Schistosoma Haematobium Infection

Schistosoma Hematobium Infection

Schistosomiasis Due To Schistosoma Haematobium

Bladder Schistosomiasis

Cystitis With Bilharziasis

Schistosoma Haematobium

Schistosoma Hematobium Infectious Disease

Schistosomiasis Of Bladder

Vesical Schistosomiasis

Schistosomiasis Urinary

Schistosomiasis Haematobia

Genitourinary Bilharziasis

Genitourinary Tract Schistosomiasis

Schistosomiasis Due To Schistosoma Haematobium [Urinary Schistosomiasis]

Haematochyluria In Schistosomiasis

Infection Due To Schistosoma Matthei
Angioedema, Hereditary, 1

Hereditary Angioedema Type I

Hereditary Angioneurotic Edema

Hane

C1 Esterase Inhibitor Deficiency

Angioedema, Hereditary, 1 And 2

HAE1

Angioneurotic Edema, Hereditary

Angioedema, Hereditary, Type I

Hereditary Angioedema Type 2

Hae 2

Hae-Ii

Hereditary Angioneurotic Edema Type 2

Angioedema, Hereditary

HAE

Angioedema, Hereditary, Types I And Ii

Hereditary Angioedema, Type Ii

Angioedema, Hereditary, Type 1

Angioedemas, Hereditary

Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor

Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

Hereditary Angioedema Types I And Ii
Hypertelorism

Eyes Wide Apart

Eyes Widely Set

Hypertelorism Of Orbit

Ocular Hypertelorism

Orbital Separation Excessive
Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome

Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

Atypical Hemolytic Uremic Syndrome

Hemolytic Uremic Syndrome, Atypical, Susceptibility To

Ahus

AHUS1

Hemolytic-Uremic Syndrome

Ahus 1

Ahus, Susceptibility To, 1

Hemolytic Uremic Syndrome, Atypical

Non-Shiga-Like Toxin-Associated Hus

Non-Stx-Hus

Nonenteropathic Hus

Atypical Hus

Shiga Toxin-Associated Hemolytic Uremic Syndrome

D+ Hus

Ehec-Hus

Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

Hemolytic Uremic Syndrome With Diarrhea

Stec-Hus

Shiga-Like Toxin-Associated Hus

Stx-Hus

Typical Hus

Typical Hemolytic Uremic Syndrome

Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

Atypical Hus With Anti-Factor H Antibodies

Ahus With Anti-Factor H Antibodies

Ahus With Neutralizing Autoantibodies Against Factor H

Hemolytic Uremic Syndrome Atypical 1

Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

D Hus

Hemolytic-Uremic Syndrome Without Diarrhea

Hemolytic-Uremic Syndrome, Atypical, Type 1

Hemolytic Uremic Syndrome, Typical
Orofacial Cleft

Cleft, Orofacial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03004 COLEC11 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus COLEC11 RGD RGD:1309678
Bos taurus COLEC11 VGNC VGNC:27578
Canis familiaris COLEC11 VGNC VGNC:39489
Macaca mulatta COLEC11 VGNC VGNC:71194
Felis catus COLEC11 VGNC VGNC:61072
Mus musculus COLEC11 MGD MGI:1918943
Others COLEC11 NCBI