2. Gene
  3. OTUB2 - OTU deubiquitinase, ubiquitin aldehyde binding 2 Gene

OTUB2 - OTU deubiquitinase, ubiquitin aldehyde binding 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as OTB2; OTU2; C14orf137

Gene ID: 78990 | Gene type: protein coding

About OTUB2

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:94,026,340-94,048,930 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 167 orthologues and 1 paralogue. Broad expression in testis (RPKM 3.4), skin (RPKM 2.0) and 18 other tissues.

Summary

This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]

OTUB2 Products(1)

mRNA Protein Name
NM_023112.4 NP_075601.1 ubiquitin thioesterase OTUB2

OTUB2 Protein Structure

Peptidase_C65

Peptidase_C65: Peptidase C65 Otubain (2 - 229)

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  • 234 a.a.
Protein Preferred Names Protein Names

ubiquitin thioesterase OTUB2

OTU domain, ubiquitin aldehyde binding 2

Recombinant OTUB2 Proteins

Cat. No. Product Name Accession Purity
HY-P71182 OTUB2 Protein, Human (GST) Q96DC9 (M1-H234) ≥95%
HY-P77118 OTUB2 Protein, Human (His) Q96DC9 (M1-H234) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149482 LN5P45 Inhibitor 99.05% Unkown
HY-160768 OTUB2-IN-1 Inhibitor / Unkown
HY-RS09870 OTUB2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus OTUB2 VGNC VGNC:32492
Mus musculus OTUB2 MGD MGI:1915399
Macaca mulatta OTUB2 VGNC VGNC:75656
Rattus norvegicus OTUB2 RGD RGD:1306688
Felis catus OTUB2 VGNC VGNC:80887
Canis familiaris OTUB2 VGNC VGNC:44183
Others OTUB2 NCBI