2. Gene
  3. BAG6 - BAG cochaperone 6 Gene

BAG6 - BAG cochaperone 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as G3; BAT3; BAG-6; D6S52E

Gene ID: 7917 | Gene type: protein coding

About BAG6

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,639,028-31,652,661 (from NCBI)

This gene has 33 transcripts (splice variants), 1 gene allele and 242 orthologues. Broad expression in testis (RPKM 77.2), spleen (RPKM 25.1) and 25 other tissues.

Summary

This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by Caspase 3 and is implicated in the control of Apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BAG6 Products(59)

mRNA Protein Name
NM_001098534.2 NP_001092004.1 large proline-rich protein BAG6 isoform 2
NM_001199697.2 NP_001186626.1 large proline-rich protein BAG6 isoform 3
NM_001199698.2 NP_001186627.1 large proline-rich protein BAG6 isoform 4
NM_001387940.1 NP_001374869.1 large proline-rich protein BAG6 isoform 4
NM_001387942.1 NP_001374871.1 large proline-rich protein BAG6 isoform 22
NM_001387943.1 NP_001374872.1 large proline-rich protein BAG6 isoform 20
NM_001387944.1 NP_001374873.1 large proline-rich protein BAG6 isoform 21
NM_001387946.1 NP_001374875.1 large proline-rich protein BAG6 isoform 20
NM_001387949.1 NP_001374878.1 large proline-rich protein BAG6 isoform 4
NM_001387951.1 NP_001374880.1 large proline-rich protein BAG6 isoform 25
NM_001387954.1 NP_001374883.1 large proline-rich protein BAG6 isoform 12
NM_001387955.1 NP_001374884.1 large proline-rich protein BAG6 isoform 19
NM_001387956.1 NP_001374885.1 large proline-rich protein BAG6 isoform 4
NM_001387958.1 NP_001374887.1 large proline-rich protein BAG6 isoform 18
NM_001387961.1 NP_001374890.1 large proline-rich protein BAG6 isoform 2
NM_001387963.1 NP_001374892.1 large proline-rich protein BAG6 isoform 15
NM_001387964.1 NP_001374893.1 large proline-rich protein BAG6 isoform 14
NM_001387965.1 NP_001374894.1 large proline-rich protein BAG6 isoform 12
NM_001387982.1 NP_001374911.1 large proline-rich protein BAG6 isoform 14
NM_001387983.1 NP_001374912.1 large proline-rich protein BAG6 isoform 13
NM_001387984.1 NP_001374913.1 large proline-rich protein BAG6 isoform 12
NM_001387985.1 NP_001374914.1 large proline-rich protein BAG6 isoform 11
NM_001387986.1 NP_001374915.1 large proline-rich protein BAG6 isoform 2
NM_001387987.1 NP_001374916.1 large proline-rich protein BAG6 isoform 10
NM_001387988.1 NP_001374917.1 large proline-rich protein BAG6 isoform 6
NM_001387989.1 NP_001374918.1 large proline-rich protein BAG6 isoform 5
NM_001387990.1 NP_001374919.1 large proline-rich protein BAG6 isoform 10
NM_001387991.1 NP_001374920.1 large proline-rich protein BAG6 isoform 7
NM_001387992.1 NP_001374921.1 large proline-rich protein BAG6 isoform 7
NM_001387993.1 NP_001374922.1 large proline-rich protein BAG6 isoform 6
NM_001387994.1 NP_001374923.1 large proline-rich protein BAG6 isoform 5
NM_001387995.1 NP_001374924.1 large proline-rich protein BAG6 isoform 6
NM_001387996.1 NP_001374925.1 large proline-rich protein BAG6 isoform 5
NM_001387997.1 NP_001374926.1 large proline-rich protein BAG6 isoform 21
NM_001387998.1 NP_001374927.1 large proline-rich protein BAG6 isoform 19
NM_001387999.1 NP_001374928.1 large proline-rich protein BAG6 isoform 4
NM_001388000.1 NP_001374929.1 large proline-rich protein BAG6 isoform 4
NM_001388001.1 NP_001374930.1 large proline-rich protein BAG6 isoform 4
NM_001388002.1 NP_001374931.1 large proline-rich protein BAG6 isoform 17
NM_001388003.1 NP_001374932.1 large proline-rich protein BAG6 isoform 16
NM_001388004.1 NP_001374933.1 large proline-rich protein BAG6 isoform 14
NM_001388005.1 NP_001374934.1 large proline-rich protein BAG6 isoform 13
NM_001388006.1 NP_001374935.1 large proline-rich protein BAG6 isoform 12
NM_001388007.1 NP_001374936.1 large proline-rich protein BAG6 isoform 10
NM_001388008.1 NP_001374937.1 large proline-rich protein BAG6 isoform 9
NM_001388009.1 NP_001374938.1 large proline-rich protein BAG6 isoform 8
NM_001388010.1 NP_001374939.1 large proline-rich protein BAG6 isoform 6
NM_001388011.1 NP_001374940.1 large proline-rich protein BAG6 isoform 5
NM_001388012.1 NP_001374941.1 large proline-rich protein BAG6 isoform 23
NM_001388013.1 NP_001374942.1 large proline-rich protein BAG6 isoform 24
NM_001388014.1 NP_001374943.1 large proline-rich protein BAG6 isoform 4
NM_001388015.1 NP_001374944.1 large proline-rich protein BAG6 isoform 2
NM_001388016.1 NP_001374945.1 large proline-rich protein BAG6 isoform 13
NM_001388017.1 NP_001374946.1 large proline-rich protein BAG6 isoform 2
NM_001388018.1 NP_001374947.1 large proline-rich protein BAG6 isoform 2
NM_001388019.1 NP_001374948.1 large proline-rich protein BAG6 isoform 6
NM_001388020.1 NP_001374949.1 large proline-rich protein BAG6 isoform 5
NM_080702.3 NP_542433.1 large proline-rich protein BAG6 isoform 2
NM_080703.3 NP_542434.1 large proline-rich protein BAG6 isoform 2

BAG6 Protein Structure

ubiquitin

ubiquitin: Ubiquitin family (22 - 87)

DUF3538

DUF3538: Domain of unknown function (DUF3538) (270 - 386)

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  • 1126 a.a.
Protein Preferred Names Protein Names

large proline-rich protein BAG6

BAG family molecular chaperone regulator 6

Related Diseases

Diseases Alias
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01347 BAG6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BAG6 MGD MGI:1919439
Macaca mulatta BAG6 VGNC VGNC:81044
Bos taurus BAG6 VGNC VGNC:26410
Rattus norvegicus BAG6 RGD RGD:71064
Canis familiaris BAG6 VGNC VGNC:38368
Felis catus BAG6 VGNC VGNC:60069