SLC39A7 - solute carrier family 39 member 7 Gene

Homo sapiens

Also known as KE4; AGM9; HKE4; ZIP7; RING5; H2-KE4; D6S115E; D6S2244E

Gene ID: 7922 | Gene type: protein coding

About SLC39A7

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,200,867-33,204,437 (from NCBI)

This gene has 17 transcripts (splice variants), 1 gene allele, 175 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 58.8), placenta (RPKM 52.4) and 25 other tissues.

Summary

The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in Cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

SLC39A7 Products(3)

mRNA	Protein	Name
NM_001077516.2	NP_001070984.1	zinc transporter SLC39A7 isoform 1 precursor
NM_001288777.2	NP_001275706.1	zinc transporter SLC39A7 isoform 2
NM_006979.3	NP_008910.2	zinc transporter SLC39A7 isoform 1 precursor

SLC39A7 Protein Structure

Zip

0
100
200
300
400
469 a.a.

Protein Preferred Names

Protein Names

zinc transporter SLC39A7

HLA class II region expressed gene KE4

Related Diseases

Diseases

Alias

Agammaglobulinemia 9, Autosomal Recessive

AGM9	Agammaglobulinemia, Autosomal Recessive, Due To Slc39a7 Defect

Agammaglobulinemia 9

Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica	AEZ
Enteropathica	Brandt Syndrome
Ae	Acrodermatitis Enteropathica Zinc Deficiency Type
Danbolt-Cross Syndrome	Acrodermatitis Enteropathica, Zinc Deficiency Type
Inherited Zinc Deficiency	Acrodermatitis Enteropathica, Zinc Deficiency
Danbolt-Closs Syndrome	Primary Zinc Malabsorption Syndrome

Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like	Scd-Eds
EDSSPD3	Ehlers-Danlos Syndrome Spondylodysplastic Type 3
Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type	Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome
Slc39a13-Related Speds	Slc39a13-Related Spondylodysplastic Eds
Spondylocheirodysplastic Ehlers-Danlos Syndrome	Speds-Slc39a13
Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia	Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3

Enophthalmos

Ehlers-Danlos Syndrome

Eds	Cutis Hyperelastica
Elastic Skin	Ehlers-Danlos Syndromes
Ed Syndrome	Ehlers Danlos Syndrome
Ehlers Danlos Disease	Eds - [Ehlers-Danlos Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114395	NVS-ZP7-4	Inhibitor	98.58%	Unkown
HY-114395A	(R)-NVS-ZP7-4		99.00%	Unkown
HY-RS13238	SLC39A7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC39A7	VGNC	VGNC:46406
Mus musculus	SLC39A7	MGD	MGI:95909
Macaca mulatta	SLC39A7	VGNC	VGNC:77592
Rattus norvegicus	SLC39A7	RGD	RGD:1593280
Bos taurus	SLC39A7	VGNC	VGNC:34867

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