CDC73 - cell division cycle 73 Gene

Homo sapiens

Also known as HYX; FIHP; HPTJT; HRPT1; HRPT2; C1orf28

Gene ID: 79577 | Gene type: protein coding

About CDC73

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:193,122,031-193,254,815 (from NCBI)

This gene has 13 transcripts (splice variants), 215 orthologues and is associated with 92 phenotypes. Ubiquitous expression in thyroid (RPKM 11.2), prostate (RPKM 9.6) and 25 other tissues.

Summary

This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a Histone Methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]

CDC73 Products(1)

mRNA	Protein	Name
NM_024529.5	NP_078805.3	parafibromin

CDC73 Protein Structure

CDC73_C

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531 a.a.

Protein Preferred Names

Protein Names

parafibromin

Familial isolated hyperparathyroidism

Related Diseases

Diseases

Alias

Hyperparathyroidism 2 With Jaw Tumors

Hyperparathyroidism-Jaw Tumor Syndrome	Hpt-Jt
HRPT2	Familial Primary Hyperparathyroidism With Multiple Ossifying Jaw Fibromas
Parathyroid Adenoma With Cystic Changes	Hereditary Hyperparathyroidism-Jaw Tumor Syndrome
Hyperparathyroidism 2	Hyperparathyroidism, Familial Primary, With Multiple Ossifying Jaw Fibromas
Hyperparathyroidism-Jaw Tumor Syndrome, Hereditary	Familial Cystic Parathyroid Adenomatosis
Hyperparathyroidism-Jaw Tumor Syndrome, Type 2	Parathyroid Adenomatosis, Familial Cystic

Hyperparathyroidism 1

Familial Isolated Hyperparathyroidism	Fihp
HRPT1	Hyperparathyroidism, Familial Isolated Primary
Hyperparathyroidism, Familial Primary	Familial Primary Hyperparathyroidism
Fihpt	Hyperparathyroidism, Familial, Isolated, Primary
Hyperparathyroidism 3	Parathyroid Adenoma, Familial

Parathyroid Carcinoma

Parathyroid Cancer	Parathyroid Neoplasms
Malignant Tumor Of Parathyroid Gland	PRTC
Carcinoma Of Parathyroid Gland	Malignant Neoplasm Of Parathyroid Gland
Parathyroid Gland Adenocarcinoma	Parathyroid Gland Cancer
Parathyroid Neoplasm	Parathyroid Gland Carcinoma
Malignant Neoplasm Of The Parathyroid	Neoplasm Of Parathyroid Gland
Parathyroid Gland Neoplasm	Cancer Of The Parathyroid
Cancer Of The Parathyroid Gland	Malignant Neoplasm Of Parathyroid
Malignant Parathyroid Gland Neoplasm	Malignant Parathyroid Gland Tumor
Malignant Parathyroid Neoplasm	Malignant Parathyroid Tumor
Malignant Tumor Of Parathyroid	Parathyroid Adenocarcinoma
Neoplasm Of The Parathyroid Gland	Carcinoma, Parathyroid

Parathyroid Adenoma

Adenoma Of Parathyroid	Adenoma Of The Parathyroid Gland
Parathyroid Gland Adenoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Bap1 Tumor Predisposition Syndrome

Bap1-Related Tumor Predisposition Syndrome	Common Syndrome
Bap1 Cancer Syndrome	Bap1-Tpds
Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms	Tumor Predisposition Syndrome
Tumor Susceptibility Linked To Germline Bap1 Mutations	Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms
Tumor Predisposition

Inherited Cancer-Predisposing Syndrome

Hereditary Cancer-Predisposing Syndrome

Hyperparathyroidism

Hyperparathyroidism And Other Disorders Of Parathyroid Gland	Parathyroid Hyperfunction
Hpth - [Hyperparathyroidism]	Parathyroid Gland Hyperfunction
Parathyroid Glandular Hyperfunction

Ossifying Fibroma

Peripheral Ossifying Fibroma	Fibro-Osteoma
Fibroma Ossifying	Fibroma, Ossifying

Fibroma

Primary Hyperparathyroidism

Familial Primary Hyperparathyroidism	Hyperparathyroidism, Primary
Hyperparathyroidism Primary	Hypocalciuric Hypercalcemia, Familial, Type 1
Familial Benign Hypercalcemia	Familial Hyperparathyroidism
Parathyroid Enlargement

Parathyroid Gland Disease

Parathyroid Diseases	Disease Of Parathyroid Glands
Parathyroid Disease

Cdc73-Related Disorders

Multiple Endocrine Neoplasia

Men	Multiple Endocrine Adenomatosis
Multiple Endocrine Neoplasia Syndrome	Adenomatosis, Familial Endocrine
Endocrine Neoplasia, Multiple	Familial Endocrine Adenomatosis
Mea	Multiple Endocrine Neoplasms
Multiple Endocrine Neoplasia Type 1

Parathyroid Oncocytic Adenoma

Parathyroid Gland Oncocytic Adenoma

Multiple Endocrine Neoplasia, Type Iia

Multiple Endocrine Neoplasia Type 2a	Sipple Syndrome
Multiple Endocrine Neoplasia Type 2	MEN2A
Men2	Ptc Syndrome
Multiple Endocrine Neoplasia, Type 2	Multiple Endocrine Neoplasia Iia
Men 2a	Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma
Multiple Endocrine Neoplasia, Type 2a	Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma
Multiple Endocrine Neoplasia Ii	Men2 Syndrome
Men-2a Syndrome	Multiple Neoplasia 2a
Multiple Neoplasia Type 2

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Fibrous Dysplasia

Fibrous Dysplasia Of Bone

Clear Cell Adenoma

Hereditary Wilms' Tumor

Hereditary Wilms Tumor	Hereditary Wilms Tumour
Hereditary Wilms' Tumour	Wt1

Familial Hypocalciuric Hypercalcemia

Familial Benign Hypercalcemia	Fbh
Fbhh	Fhh
Familial Benign Hypocalciuric Hypercalcemia	Hypocalciuric Hypercalcemia, Familial, Type 1

Water-Clear Cell Adenoma

Bone Benign Neoplasm

Malignant Fibrous Histiocytoma Of Bone

Malignant Fibrous Histiocytoma Of The Bone

Hypocalciuric Hypercalcemia, Familial, Type I

HHC1	Familial Hypocalciuric Hypercalcemia 1
Fhh1	Familial Benign Hypercalcemia 1
Fbh1	Hypocalciuric Hypercalcemia, Type I
Fhh Type 1	Hhc
Fhh	Hypercalcemia, Familial Benign
Hypocalciuric Hypercalcemia Type I	Familial Hypocalciuric Hypercalcemia Type 1
Hypocalciuric Hypercalcemia, Familial, Type 1	Familial Hypocalciuric Hypercalcemia Type I
Familial Benign Hypercalcemia Type 1	Hypercalcemia, Familial Benign Type 1
Hypocalciuric Hypercalcemia, Familial 1	Familial Benign Hypocalciuric Hypercalcemia 1
Fbhh1

Hypocalciuric Hypercalcemia, Familial, Type Ii

HHC2	Familial Hypocalciuric Hypercalcemia 2
Fbh2	Familial Hypocalciuric Hypercalcemia Type 2
Hypocalciuric Hypercalcemia, Type Ii	Fhh Type 2
Familial Benign Hypercalcemia, Type Ii	Hypercalcemia, Familial Benign, Type Ii
Hypocalciuric Hypercalcemia Type Ii	Familial Benign Hypercalcemia, Type 2
Hypercalcemia, Familial Benign Type 2	Hypocalciuric Hypercalcemia, Familial, Type 2
Hypocalciuric Hypercalcemia, Familial 2	Familial Benign Hypercalcemia Type Ii
Hypocalciuric Hypercalcemia-2

Osteitis Fibrosa

Osteitis Fibrosa Cystica	Hyperparathyroid Bone Disease
Osteitis Fibrosa Cystica Generalisata	Von Recklinghausen'S Bone Disease
Osteitis Fibrosa Disseminata

Thyroid Gland Hurthle Cell Carcinoma

Oncocytic Carcinoma Of The Thyroid

Thyroid Cancer, Hurthle Cell

Multiple Endocrine Neoplasia, Type Iv

Multiple Endocrine Neoplasia Type 4	MEN4
Multiple Endocrine Neoplasia 4	Neoplasia, Endocrine, Multiple, Type Iv

Connective Tissue Benign Neoplasm

Soft Tissue Neoplasms	Mesenchymal Tissue Neoplasm
Neoplasm Of Soft Tissue	Neoplasm Of Soft Tissues
Soft Tissue Benign Neoplasm	Tumor Of The Soft Tissue
Soft Tissue Neoplasm

Lipoadenoma

Hypocalciuric Hypercalcemia, Familial, Type Iii

HHC3	Familial Hypocalciuric Hypercalcemia 3
Fbh3	Familial Hypocalciuric Hypercalcemia Type 3
Hypercalcemia, Familial Benign, Oklahoma Type	Hypocalciuric Hypercalcemia, Type Iii
Fhh Type 3	Hypocalciuric Hypercalcemia Type Iii
Familial Benign Hypercalcemia, Type Iii	Hypercalcemia, Familial Benign, Type Iii
Fbhok	Familial Benign Hypercalcemia, Oklahoma Variant
Familial Benign Hypercalcemia, Type 3	Hypercalcemia, Familial Benign, Type 3
Hypocalciuric Hypercalcemia, Familial, Type 3	Hypocalciuric Hypercalcemia, Familial 3
Familial Benign Hypercalcemia 3	Familial Benign Hypercalcemia Oklahoma Type
Familial Benign Hypocalciuric Hypercalcemia 3	Fbhh3
Fhh3

Epulis

Epulides	Gingival Polyp
Polyp Of Gum

Endocrine Organ Benign Neoplasm

Mineral Metabolism Disease

Mineral Metabolism Disorder

Disorder Of Mineral Metabolism

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02310	CDC73 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDC73	VGNC	VGNC:60665
Rattus norvegicus	CDC73	RGD	RGD:1311766
Bos taurus	CDC73	VGNC	VGNC:27083
Mus musculus	CDC73	MGD	MGI:2384876
Macaca mulatta	CDC73	VGNC	VGNC:70766
Canis familiaris	CDC73	VGNC	VGNC:39011