2. Gene
  3. VTCN1 - V-set domain containing T cell activation inhibitor 1 Gene

VTCN1 - V-set domain containing T cell activation inhibitor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291

Gene ID: 79679 | Gene type: protein coding

About VTCN1

Cytogenetic location: 1p13.1-p12 Genomic coordinates (GRCh38): 1:117,143,587-117,210,927 (from NCBI)

This gene has 6 transcripts (splice variants), 182 orthologues and 15 paralogues. Biased expression in kidney (RPKM 5.0), pancreas (RPKM 2.8) and 9 other tissues.

Summary

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

VTCN1 Products(3)

mRNA Protein Name
NM_001253849.2 NP_001240778.1 V-set domain-containing T-cell activation inhibitor 1 isoform 2
NM_001253850.2 NP_001240779.1 V-set domain-containing T-cell activation inhibitor 1 isoform 3
NM_024626.4 NP_078902.2 V-set domain-containing T-cell activation inhibitor 1 isoform 1 precursor

VTCN1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (46 - 138)

Ig_3

Ig_3: Immunoglobulin domain (164 - 229)

  • 0
  • 100
  • 200
  • 282 a.a.
Protein Preferred Names Protein Names

V-set domain-containing T-cell activation inhibitor 1

B7 family member, H4

Recombinant VTCN1 Proteins

Cat. No. Product Name Accession Purity
HY-P7640 B7-H4 Protein, Human (HEK293, Fc) Q7Z7D3 (F29-A258) ≥95%
HY-P72341 B7-H4 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q7Z7D3 (F29-A258) ≥95%
HY-P74395 B7-H4 Protein, Human (HEK293, His) Q7Z7D3 (F29-A258) ≥95%
HY-P77541 B7-H4 Protein, Human (Biotinylated, HEK293, His) Q7Z7D3 (F29-A258) ≥95%
HY-P78073 B7-H4 Protein, Human (Biotinylated, HEK293, His-Avi) Q7Z7D3 (F29-A258) ≥95%
HY-P78390 B7-H4 Protein, Human (HEK293, His-Avi) Q7Z7D3 (F29-A258) ≥95%

Related Diseases

Diseases Alias
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15721 VTCN1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VTCN1 VGNC VGNC:36848
Macaca mulatta VTCN1 VGNC VGNC:79749
Mus musculus VTCN1 MGD MGI:3039619
Rattus norvegicus VTCN1 RGD RGD:1311204
Canis familiaris VTCN1 VGNC VGNC:48315
Felis catus VTCN1 VGNC VGNC:66988
Others VTCN1 NCBI