ORAI2 - ORAI calcium release-activated calcium modulator 2 Gene

Homo sapiens

Also known as CBCIP2; C7orf19; MEM142B; TMEM142B

Gene ID: 80228 | Gene type: protein coding

About ORAI2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,433,575-102,456,825 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues and 2 paralogues. Broad expression in spleen (RPKM 5.4), bone marrow (RPKM 5.3) and 23 other tissues.

Summary

Predicted to enable store-operated Calcium Channel activity. Predicted to be involved in store-operated calcium entry. Predicted to be located in growth cone. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ORAI2 Products(4)

mRNA	Protein	Name
NM_001126340.3	NP_001119812.1	protein orai-2 isoform a
NM_001271818.2	NP_001258747.1	protein orai-2 isoform a
NM_001271819.2	NP_001258748.1	protein orai-2 isoform b
NM_032831.4	NP_116220.1	protein orai-2 isoform a

ORAI2 Protein Structure

Orai-1

0
100
200
254 a.a.

Protein Preferred Names

Protein Names

protein orai-2

CAP-binding protein complex interacting protein 2

Related Diseases

Diseases

Alias

Immunodeficiency 10

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2	Combined Immunodeficiency Due To Stim1 Deficiency
IMD10	Stim1 Deficiency
Cid Due To Stim1 Deficiency	Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2
Immunodeficiency, Type 10

T Cell And Nk Cell Immunodeficiency

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis	Stormorken-Sjaastad-Langslet Syndrome
STRMK	York Platelet Syndrome
Yps	Thrombocytopathy, Asplenia And Miosis
Thrombocytopathy Asplenia Miosis	Thrombocytopathy-Asplenia-Miosis Syndrome
Miosis Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101942	Zegocractin	Inhibitor	99.93%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09823	ORAI2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ORAI2	MGD	MGI:2443195
Felis catus	ORAI2	VGNC	VGNC:63972
Macaca mulatta	ORAI2	VGNC	VGNC:75665
Rattus norvegicus	ORAI2	RGD	RGD:1310213
Canis familiaris	ORAI2	VGNC	VGNC:44138
Bos taurus	ORAI2	VGNC	VGNC:32444

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