KDM7A - lysine demethylase 7A Gene

Homo sapiens

Also known as JHDM1D

Gene ID: 80853 | Gene type: protein coding

About KDM7A

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:140,084,746-140,176,983 (from NCBI)

This gene has 3 transcripts (splice variants), 244 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 9.6), colon (RPKM 7.1) and 25 other tissues.

Summary

Enables Histone Demethylase activity; methylated histone binding activity; and transition metal ion binding activity. Involved in histone lysine demethylation. Located in nucleolus and nucleoplasm. Implicated in melanoma. [provided by Alliance of Genome Resources, Apr 2022]

KDM7A Products(1)

mRNA	Protein	Name
NM_030647.2	NP_085150.1	lysine-specific demethylase 7A

KDM7A Protein Structure

PHD

JmjC

0
200
400
600
800
941 a.a.

Protein Preferred Names

Protein Names

lysine-specific demethylase 7A

[histone H3]-dimethyl-L-lysine9 demethylase 7A

Related Diseases

Diseases

Alias

Syndromic X-Linked Intellectual Disability Siderius Type

Mrxssd	Siderius-Hamel Syndrome
Siderius X-Linked Mental Retardation Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107573	KDM2/7-IN-1	Inhibitor	≥99.0%	Unkown
HY-RS07224	KDM7A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KDM7A	VGNC	VGNC:63074
Canis familiaris	KDM7A	VGNC	VGNC:51806
Rattus norvegicus	KDM7A	RGD	RGD:1592650
Mus musculus	KDM7A	MGD	MGI:2443388
Bos taurus	KDM7A	VGNC	VGNC:30533
Macaca mulatta	KDM7A	VGNC	VGNC:73886

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