AMN - amnion associated transmembrane protein Gene

Homo sapiens

Also known as IGS2; PRO1028; amnionless

Gene ID: 81693 | Gene type: protein coding

About AMN

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:102,922,663-102,930,842 (from NCBI)

This gene has 7 transcripts (splice variants), 163 orthologues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 39.0), small intestine (RPKM 30.0) and 4 other tissues.

Summary

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]

AMN Products(1)

mRNA	Protein	Name
NM_030943.4	NP_112205.2	protein amnionless precursor

AMN Protein Structure

Amnionless

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

protein amnionless

amnionless homolog

Related Diseases

Diseases

Alias

Imerslund-Grasbeck Syndrome 2

IGS2	Megaloblastic Anemia, Norwegian Type
Imerslund-Grasbeck Syndrome Type 2

Megaloblastic Anemia

Imerslund-Grasbeck Syndrome	Igs
Defect Of Enterocyte Intrinsic Factor Receptor	Enterocyte Cobalamin Malabsorption
Familial Megaloblastic Anemia	Megaloblastic Anemia 1
Selective Cobalamin Malabsorption With Proteinuria	Imerslund-Gräsbeck Syndrome
Anemia, Megaloblastic	Grasbeck-Imerslund Syndrome
Megaloblastic Anaemia	Mga1 Norwegian Type
Recessive Hereditary Megaloblastic Anaemia 1	Recessive Hereditary Megaloblastic Anemia 1
Rh-Mga1	Gräsbeck-Imerslund Disease
Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria	Juvenile Pernicious Anemia With Proteinuria Due To Selective Intestinal Malabsorption Of Vitamin B12
Anemia Megaloblastic	Megaloblastic Anemia Due To Inborn Errors Of Metabolism
3-@Methylglutaconic Aciduria, Type I

Vitamin B12 Deficiency

Cobalamin Deficiency	Hypocobalaminemia
Vitamin B 12 Deficiency	Cyanocobalamin Deficiency
Deficiency Of Vitamin B12

Imerslund-Grasbeck Syndrome 1

Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria	IGS1
Megaloblastic Anemia, Finnish Type	Mga1
Enterocyte Cobalamin Malabsorption	Imerslund-Grasbeck Syndrome Type 1
Megaloblastic Anemia, 1	Enterocyte Intrinsic Factor Receptor, Defect Of
Defect Of Enterocyte Intrinsic Factor Receptor	Megaloblastic Anemia 1

Congenital Intrinsic Factor Deficiency

Hereditary Intrinsic Factor Deficiency	Intrinsic Factor Deficiency
Congenital Pernicious Anemia	Gastric Intrinsic Factor Deficiency
Hereditary Juvenile Megaloblastic Anemia Due To Intrinsic Factor Deficiency	Ifd
Intrinsic Factor Deficiency, Congenital, Susceptibility To	Congenital Deficiency Of Intrinsic Factor
Megaloblastic Anemia Due To Inborn Errors Of Metabolism

Donnai-Barrow Syndrome

Faciooculoacousticorenal Syndrome	Dbs/Foar Syndrome
Foar Syndrome	Diaphragmatic Hernia-Exomphalos-Hypertelorism Syndrome
Facio-Oculo-Acoustico-Renal Syndrome	Diaphragmatic Hernia, Exomphalos, Absent Corpus Callosum, Hypertelorism, Myopia, Sensorineural Deafness, And Proteinuria
Diaphragmatic Hernia-Hypertelorism-Myopia-Deafness Syndrome	Holmes-Schepens Syndrome
Syndrome Of Ocular And Facial Anomalies, Telecanthus And Deafness	DBS
Diaphragmatic Hernia Exomphalos Absent Corpus Callosum Hypertelorism Myopia Sensorineural Deafness And Proteinuria	Diaphragmatic Hernia-Exomphalos-Corpus Callosum Agenesis
Diaphragmatic Hernia-Hypertelorism-Myopia-Hearing Loss Syndrome	Syndrome Of Ocular And Facial Anomalies, Telecanthus And Hearing Loss
Donnai Barrow Syndrome

Tropical Sprue

Tropical Steatorrhea	Tropical Enteropathy
Sprue, Tropical	Sprue - Tropical
Idiopathic Tropical Malabsorption Syndrome	Tropical Steatorrhoea
Tropical Diarrhoea	Ts - [Tropical Sprue]
Psilosis	Sprue Nos

Vitamin Metabolic Disorder

Dent Disease 1

Dent Disease	Dent'S Disease
Dent Disease 2	Dent Disease Type 1
DENT1	Urolithiasis, Hypercalciuric, X-Linked
Nephrolithiasis 2	Nphl2
Dent Syndrome	Dents Disease
Low-Molecular-Weight Proteinuria With Hypercalciuria And Nephrocalcinosis	Renal Fanconi Syndrome With Nephrocalcinosis And Renal Stones
X-Linked Recessive Hypercalciuric Hypophosphatemic Rickets	X-Linked Recessive Nephrolithiasis
Fanconi Syndrome, Renal, With Nephrocalcinosis And Renal Stones	Nephrolithiasis, Hypercalciuric, X-Linked
Nephrolithiasis-Hypercalciuria X-Linked Recessive	Nephrolithiasis, X-Linked Recessive
Dent Disease, Type 1

Macrocytic Anemia

Anemia Macrocytic	Anemia, Macrocytic
Macrocytic Anaemia

Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive	Arh
FHCL4	Autosomal Recessive Hypercholesterolemia
Arh1	Arh2
Autosomal Recessive Hypercholesterolemia 1	Autosomal Recessive Hypercholesterolemia 2
Fhcb1	Fhcb2
Hypercholesterolemia, Autosomal Recessive, 1, Formerly	Arh1, Formerly
Fhcb1, Formerly	Hypercholesterolemia, Autosomal Recessive, 2, Formerly
Arh2, Formerly	Fhcb2, Formerly
Familial Autosomal Recessive Hypercholesterolemia	Hypercholesterolemia, Familial, Autosomal Recessive
Hypercholesterolemia, Familial, Type 4

Pernicious Anemia

Anemia, Pernicious	Anemia Pernicious
Pernicious Anaemia	Addison'S Anaemia
Biermer'S Anaemia	Biermer'S Anemia
Acquired Pernicious Anemia	Addison-Biermer Anemia
Addisonian Anemia	Biermer Anemia
Biermer'S Disease	Juvenile Onset Pernicious Anemia
Biermer Disease	Biermer-Addison Disease

Glossitis

Inflammation Of Tongue	Tongue Inflammation
Glazed Tongue

Methylmalonic Acidemia

Methylmalonic Aciduria	Mma
Acidemia, Methylmalonic	Isolated Methylmalonic Acidemia

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Hypophosphatemic Rickets, X-Linked Recessive

Hypophosphatemic Rickets	X-Linked Recessive Hypophosphatemic Rickets
XLRHR	Hypophosphatemic Rickets Disorders
Rickets Hypophosphatemic	Rickets, Hypophosphatemic, X-Linked Recessive
Familial Hypophosphatemic Rickets

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-10159	Nilotinib	99.93%	Yes
HY-10159A	Nilotinib monohydrochloride monohydrate	99.89%	Yes
HY-10159B	Nilotinib hydrochloride	/	Unkown

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113301	Hexacosanoic acid		≥95.0%	Unkown
HY-103565	AMN082	Agonist	99.73%	Unkown
HY-10159S	Nilotinib-d6		99.95%	Unkown
HY-103565A	AMN082 free base	Agonist	99.07%	Unkown
HY-113301S	Hexacosanoic acid-d4		/	Unkown
HY-113301S1	Hexacosanoic acid-d4-1		≥98.0%	Unkown
HY-RS00661	AMN Human Pre-designed siRNA Set A		/	Unkown
HY-RS00662	AMN1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AMN	MGD	MGI:1934943
Bos taurus	AMN	VGNC	VGNC:25869
Rattus norvegicus	AMN	RGD	RGD:1308634
Macaca mulatta	AMN	VGNC	VGNC:107993
Others	AMN	NCBI

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