2. Gene
  3. BCAR3 - BCAR3 adaptor protein, NSP family member Gene

BCAR3 - BCAR3 adaptor protein, NSP family member Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MIG7; NSP2; AND-34; SH2D3B

Gene ID: 8412 | Gene type: protein coding

About BCAR3

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,561,741-93,847,219 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 13.8), placenta (RPKM 6.5) and 23 other tissues.

Summary

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast Cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast Cancer cells. The protein contains a putative Src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

BCAR3 Products(33)

mRNA Protein Name
NM_001261408.2 NP_001248337.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001261409.1 NP_001248338.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001261410.2 NP_001248339.1 breast cancer anti-estrogen resistance protein 3 isoform 2
NM_001308251.1 NP_001295180.1 breast cancer anti-estrogen resistance protein 3 isoform 3
NM_001412043.1 NP_001398972.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412044.1 NP_001398973.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412045.1 NP_001398974.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412046.1 NP_001398975.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412048.1 NP_001398977.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412049.1 NP_001398978.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412050.1 NP_001398979.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412051.1 NP_001398980.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412052.1 NP_001398981.1 breast cancer anti-estrogen resistance protein 3 isoform 1
NM_001412054.1 NP_001398983.1 breast cancer anti-estrogen resistance protein 3 isoform 4
NM_001412055.1 NP_001398984.1 breast cancer anti-estrogen resistance protein 3 isoform 5
NM_001412056.1 NP_001398985.1 breast cancer anti-estrogen resistance protein 3 isoform 6
NM_001412057.1 NP_001398986.1 breast cancer anti-estrogen resistance protein 3 isoform 7
NM_001412058.1 NP_001398987.1 breast cancer anti-estrogen resistance protein 3 isoform 8
NM_001412059.1 NP_001398988.1 breast cancer anti-estrogen resistance protein 3 isoform 9
NM_001412060.1 NP_001398989.1 breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412061.1 NP_001398990.1 breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412062.1 NP_001398991.1 breast cancer anti-estrogen resistance protein 3 isoform 10
NM_001412064.1 NP_001398993.1 breast cancer anti-estrogen resistance protein 3 isoform 12
NM_001412065.1 NP_001398994.1 breast cancer anti-estrogen resistance protein 3 isoform 13
NM_001412066.1 NP_001398995.1 breast cancer anti-estrogen resistance protein 3 isoform 14
NM_001412067.1 NP_001398996.1 breast cancer anti-estrogen resistance protein 3 isoform 15
NM_001412072.1 NP_001399001.1 breast cancer anti-estrogen resistance protein 3 isoform 14
NM_001412073.1 NP_001399002.1 breast cancer anti-estrogen resistance protein 3 isoform 16
NM_001412074.1 NP_001399003.1 breast cancer anti-estrogen resistance protein 3 isoform 17
NM_001412075.1 NP_001399004.1 breast cancer anti-estrogen resistance protein 3 isoform 18
NM_001412076.1 NP_001399005.1 breast cancer anti-estrogen resistance protein 3 isoform 19
NM_001412077.1 NP_001399006.1 breast cancer anti-estrogen resistance protein 3 isoform 8
NM_003567.4 NP_003558.1 breast cancer anti-estrogen resistance protein 3 isoform 1

BCAR3 Protein Structure

SH2

SH2: SH2 domain (154 - 234)

RasGEF

RasGEF: RasGEF domain (597 - 696)

  • 0
  • 200
  • 400
  • 600
  • 825 a.a.
Protein Preferred Names Protein Names

breast cancer anti-estrogen resistance protein 3

BCAR3, NSP family adaptor protein

Related Diseases

Diseases Alias
Estrogen Resistance

Estrogen Resistance Syndrome

ESTRR

Estrogen Insensitivity
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01398 BCAR3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BCAR3 VGNC VGNC:70235
Mus musculus BCAR3 MGD MGI:1352501
Felis catus BCAR3 VGNC VGNC:69195
Canis familiaris BCAR3 VGNC VGNC:49077
Rattus norvegicus BCAR3 RGD RGD:1311688
Bos taurus BCAR3 VGNC VGNC:53850