CHD6 - chromodomain helicase DNA binding protein 6 Gene

Homo sapiens

Also known as CHD5; RIGB; CHD-6

Gene ID: 84181 | Gene type: protein coding

About CHD6

Cytogenetic location: 20q12 Genomic coordinates (GRCh38): 20:41,402,083-41,618,377 (from NCBI)

This gene has 8 transcripts (splice variants), 194 orthologues and 30 paralogues. Ubiquitous expression in ovary (RPKM 7.0), thyroid (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of Influenza Virus replication. [provided by RefSeq, Jul 2013]

CHD6 Products(1)

mRNA	Protein	Name
NM_032221.5	NP_115597.3	chromodomain-helicase-DNA-binding protein 6

CHD6 Protein Structure

Chromo

SNF2_N

Helicase_C

BRK

0
500
1000
1500
2000
2500
2715 a.a.

Protein Preferred Names

Protein Names

chromodomain-helicase-DNA-binding protein 6

ATP-dependent helicase CHD6

Related Diseases

Diseases

Alias

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Pitt-Hopkins Syndrome

PTHS	Encephalopathy, Severe Epileptic, With Autonomic Dysfunction
Mental Retardation, Syndromal, With Intermittent Hyperventilation	Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea
Pitt Hopkins Syndrome	Phs
Encephalopathy Severe Epileptic With Autonomic Dysfunction

Schizophrenia 8

SCZD8	Schizophrenia Susceptibility Locus, Chromosome 18-Related
Schizophrenia 8 With Or Without An Affective Disorder

Hallermann-Streiff Syndrome

Francois Dyscephalic Syndrome	HSS
Hallermann'S Syndrome	Oculomandibulofacial Syndrome
Hallerman - Streiff Syndrome	François Dyscephalic Syndrome
Hallermann Streiff Francois Syndrome	Hallermann Streiff Syndrome

Adult Spinal Cord Ependymoma

Charge Syndrome

Charge Association	Hall-Hittner Syndrome
Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies	Hhs
Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies	Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome
CHARGES

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02611	CHD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHD6	MGD	MGI:1918639
Bos taurus	CHD6	VGNC	VGNC:27281
Canis familiaris	CHD6	VGNC	VGNC:39204
Felis catus	CHD6	VGNC	VGNC:60847
Macaca mulatta	CHD6	VGNC	VGNC:71022
Rattus norvegicus	CHD6	RGD	RGD:1310465

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