TMEM175 - transmembrane protein 175 Gene

Homo sapiens

Also known as hTMEM175

Gene ID: 84286 | Gene type: protein coding

About TMEM175

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:932,460-958,656 (from NCBI)

This gene has 22 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in spleen (RPKM 10.8), brain (RPKM 6.7) and 25 other tissues.

Summary

Enables potassium ion leak channel activity. Involved in potassium ion transmembrane transport. Located in endosome and lysosome. Is integral component of endosome membrane and integral component of lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMEM175 Products(7)

mRNA	Protein	Name
NM_001297423.2	NP_001284352.1	endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297424.2	NP_001284353.1	endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297425.2	NP_001284354.1	endosomal/lysosomal potassium channel TMEM175 isoform 2
NM_001297426.2	NP_001284355.1	endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_001297427.2	NP_001284356.1	endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_001297428.2	NP_001284357.1	endosomal/lysosomal potassium channel TMEM175 isoform 3
NM_032326.4	NP_115702.1	endosomal/lysosomal potassium channel TMEM175 isoform 1

TMEM175 Protein Structure

DUF1211

0
100
200
300
400
504 a.a.

Protein Preferred Names

Protein Names

endosomal/lysosomal potassium channel TMEM175

endosomal/lysomomal potassium channel TMEM175

Related Diseases

Diseases

Alias

Meier-Gorlin Syndrome 3

MGORS3

Meier-Gorlin Syndrome, Type 3

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14683	TMEM175 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TMEM175	VGNC	VGNC:79736
Bos taurus	TMEM175	VGNC	VGNC:35999
Felis catus	TMEM175	VGNC	VGNC:66291
Rattus norvegicus	TMEM175	RGD	RGD:1309712
Mus musculus	TMEM175	MGD	MGI:1919642
Canis familiaris	TMEM175	VGNC	VGNC:47500

Name
Email *

	Sorry, but the email address you supplied was invalid.