2. Gene
  3. Ikbkb - inhibitor of nuclear factor kappa B kinase subunit beta Gene

Ikbkb - inhibitor of nuclear factor kappa B kinase subunit beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as IKK2; AIM-1

Gene ID: 84351 | Gene type: protein coding

About Ikbkb

Primary_assembly 16: 69,319,554-69,373,250 forward strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 198 orthologues, 3 paralogues and is associated with 36 phenotypes. Biased expression in Spleen (RPKM 138.6), Thymus (RPKM 121.8) and 9 other tissues.

Summary

Enables ATP binding activity. Contributes to IkappaB kinase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; response to cholecystokinin; and response to lipopolysaccharide. Located in cytosol and intracellular membrane-bounded organelle. Part of IkappaB kinase complex. Used to study muscular atrophy and pneumonia. Biomarker of Alzheimer's disease; colitis; colon cancer; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in breast cancer; combined immunodeficiency (multiple); dermatitis; prostate Cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Ikbkb Products(1)

mRNA Protein Name
NM_053355.3 NP_445807.2 inhibitor of nuclear factor kappa-B kinase subunit beta

Ikbkb Protein Structure

STKc_IKK_beta

STKc_IKK_beta: cd14038 (19 - 308)

Ubl_IKKA_like

Ubl_IKKA_like: cd17046 (309 - 389)

IKBKB_SDD

IKBKB_SDD: pfam18397 (388 - 662)

IKKbetaNEMObind

IKKbetaNEMObind: pfam12179 (705 - 741)

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  • 757 a.a.
Protein Preferred Names Protein Names

inhibitor of nuclear factor kappa-B kinase subunit beta

I-kappa-B kinase 2

I-kappa-B-kinase beta

IKK-B

IKK-beta

NFKBIKB

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

inhibitor of kappaB kinase beta

inhibitor of nuclear factor kappa B kinase beta subunit

nuclear factor NF-kappa-B inhibitor kinase beta

serine/threonine protein kinase IKBKB

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06659 Ikbkb Mouse Pre-designed siRNA Set A / Unkown
HY-RS06658 IKBKB Human Pre-designed siRNA Set A / Unkown
HY-RS06660 Ikbkb Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ikbkb NCBI NCBI:3551