PROK1 - prokineticin 1 Gene

Homo sapiens

Also known as PK1; PRK1; EGVEGF

Gene ID: 84432 | Gene type: protein coding

About PROK1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,451,149-110,457,358 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 1 paralogue. Biased expression in ovary (RPKM 72.8), testis (RPKM 51.2) and 2 other tissues.

Summary

The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]

PROK1 Products(1)

mRNA	Protein	Name
NM_032414.3	NP_115790.1	prokineticin-1 precursor

PROK1 Protein Structure

Prokineticin

0
105 a.a.

Protein Preferred Names

Protein Names

prokineticin-1

EG-VEGF

Recombinant PROK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71906	Prokineticin-1/EG-VEGF Protein, Human	P58294 (A20-F105)	≥95%
HY-P74616	Prokineticin-1/EG-VEGF Protein, Human (sf9, His)	P58294 (M1-F105)	≥95%

Related Diseases

Diseases

Alias

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Endocervicitis

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11194	PROK1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PROK1	MGD	MGI:2180370
Macaca mulatta	PROK1	VGNC	VGNC:76284
Felis catus	PROK1	VGNC	VGNC:80324
Rattus norvegicus	PROK1	RGD	RGD:620898
Canis familiaris	PROK1	VGNC	VGNC:45010
Bos taurus	PROK1	VGNC	VGNC:33361
Others	PROK1	NCBI

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