2. Gene
  3. PLCD4 - phospholipase C delta 4 Gene

PLCD4 - phospholipase C delta 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 84812 | Gene type: protein coding

About PLCD4

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,607,899-218,637,175 (from NCBI)

This gene has 15 transcripts (splice variants), 294 orthologues and 14 paralogues. Broad expression in esophagus (RPKM 2.6), testis (RPKM 2.2) and 23 other tissues.

Summary

This gene encodes a member of the delta class of Phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for Cancer. [provided by RefSeq, Jan 2011]

PLCD4 Products(1)

mRNA Protein Name
NM_032726.4 NP_116115.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

PLCD4 Protein Structure

EF-hand_10

EF-hand_10: EF hand (153 - 203)

EF-hand_like

EF-hand_like: Phosphoinositide-specific phospholipase C, efhand-like (207 - 289)

PI-PLC-X

PI-PLC-X: Phosphatidylinositol-specific phospholipase C, X domain (292 - 436)

PI-PLC-Y

PI-PLC-Y: Phosphatidylinositol-specific phospholipase C, Y domain (493 - 609)

C2

C2: C2 domain (630 - 718)

  • 0
  • 200
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  • 600
  • 762 a.a.
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

PLC delta4

Related Diseases

Diseases Alias
Colorectal Cancer, Hereditary Nonpolyposis, Type 4

HNPCC4

Hereditary Nonpolyposis Colorectal Cancer Type 4

Hereditary Non-Polyposis Colorectal Cancer 4

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10658 PLCD4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLCD4 MGD MGI:107469
Bos taurus PLCD4 VGNC VGNC:32986
Canis familiaris PLCD4 VGNC VGNC:44649
Felis catus PLCD4 VGNC VGNC:68898
Rattus norvegicus PLCD4 RGD RGD:621025
Macaca mulatta PLCD4 VGNC VGNC:76167