2. Gene
  3. FCRLA - Fc receptor like A Gene

FCRLA - Fc receptor like A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2

Gene ID: 84824 | Gene type: protein coding

About FCRLA

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,707,229-161,714,352 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 32.1), spleen (RPKM 21.2) and 3 other tissues.

Summary

This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by Antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

FCRLA Products(9)

mRNA Protein Name
NM_001184866.2 NP_001171795.2 Fc receptor-like A isoform 1 precursor
NM_001184867.2 NP_001171796.2 Fc receptor-like A isoform 3 precursor
NM_001184870.2 NP_001171799.2 Fc receptor-like A isoform 4 precursor
NM_001184871.2 NP_001171800.2 Fc receptor-like A isoform 7 precursor
NM_001184872.2 NP_001171801.2 Fc receptor-like A isoform 5
NM_001184873.2 NP_001171802.2 Fc receptor-like A isoform 6 precursor
NM_001366195.2 NP_001353124.2 Fc receptor-like A isoform 8 precursor
NM_001366196.2 NP_001353125.2 Fc receptor-like A isoform 9 precursor
NM_032738.4 NP_116127.4 Fc receptor-like A isoform 2 precursor

FCRLA Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (103 - 174)

Ig_2

Ig_2: Immunoglobulin domain (194 - 283)

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  • 382 a.a.
Protein Preferred Names Protein Names

Fc receptor-like A

Fc receptor homolog expressed in B cells (FREB)

Related Diseases

Diseases Alias
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04848 FCRLA Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FCRLA RGD RGD:1306176
Felis catus FCRLA VGNC VGNC:62217
Mus musculus FCRLA MGD MGI:2138647
Canis familiaris FCRLA VGNC VGNC:40810
Bos taurus FCRLA VGNC VGNC:28939
Macaca mulatta FCRLA VGNC VGNC:72526