2. Gene
  3. CDK13 - cyclin dependent kinase 13 Gene

CDK13 - cyclin dependent kinase 13 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CHED; CDC2L; CDC2L5; hCDK13; CHDFIDD

Gene ID: 8621 | Gene type: protein coding

About CDK13

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:39,950,256-40,099,580 (from NCBI)

This gene has 23 transcripts (splice variants), 207 orthologues, 26 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 7.7), lymph node (RPKM 7.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]

CDK13 Products(5)

mRNA Protein Name
NM_003718.5 NP_003709.3 cyclin-dependent kinase 13 isoform 1
XM_017012751.3 XP_016868240.1 cyclin-dependent kinase 13 isoform X2
XM_011515597.4 XP_011513899.1 cyclin-dependent kinase 13 isoform X3
NM_031267.3 NP_112557.2 cyclin-dependent kinase 13 isoform 2
XM_017012750.3 XP_016868239.1 cyclin-dependent kinase 13 isoform X1

CDK13 Protein Structure

Pkinase

Pkinase: Protein kinase domain (706 - 997)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1512 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 13

CDC2-related protein kinase 5

cell division cycle 2-like protein kinase 5

cell division protein kinase 13

cholinesterase-related cell division controller

Related Diseases

Diseases Alias
Retinitis Pigmentosa 62

RP62

Retinitis Pigmentosa, Type 62
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder

CHDFIDD

Cdk13-Related Chdfidd

Cdk13-Related Disorder

Cdk13-Related Congenital Heart Defects, Dysmorphic Facial Features, Intellectual Developmental Disorder
Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Ptosis

Blepharoptosis

Drooping Eyelid

Droopy Eyelid

Ptosis Of Eyelid

Paralysis Of Levator Palpebrae Superioris
White-Sutton Syndrome

WHSUS

Mrd37

Intellectual Disability-Microcephaly-Strabismus-Behavioral Abnormalities Syndrome

Mental Retardation, Autosomal Dominant 37

Autosomal Dominant Mental Retardation 37

Pogz-Related Intellectual Disability Syndrome
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Corneal Endothelial Dystrophy

Congenital Hereditary Endothelial Dystrophy Of Cornea

Chandler Syndrome

CHED

Chandler'S Syndrome

Endothelial Corneal Dystrophy

Ched2

Maumenee Corneal Dystrophy

Corneal Dystrophy, Congenital Hereditary Endothelial

Dystrophy Of Corneal Endothelium

Corneal Endothelial Dystrophy 2

Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly

Ched2, Formerly

Corneal Endothelial Dystrophy, Autosomal Recessive

Endothelial Dystrophy

Posterior Membrane Corneal Dystrophy

Corneal Endothelial Dystrophy Type 2

Congenital Hereditary Endothelial Dystrophy Of The Cornea

Congenital Hereditary Endothelial Dystrophy Type Ii

Autosomal Recessive Ched

Autosomal Recessive Congenital Hereditary Endothelial Dystrophy

Chedii

Congenital Hereditary Endothelial Dystrophy Type 2

Infantile Hereditary Endothelial Dystrophy

Congenital Hereditary Endothelial Corneal Dystrophy

Corneal Endothelial Dystrophy 2, Autosomal Recessive

Iridocorneal Endothelial Syndrome

Dystrophy, Corneal, Endothelial

Corneal Endothelial Dystrophy 1, Autosomal Dominant
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Corneal Dystrophy, Posterior Polymorphous, 1

Posterior Polymorphous Corneal Dystrophy

Ppcd

Maumenee Corneal Dystrophy

Posterior Polymorphous Corneal Dystrophy 1

PPCD1

Corneal Dystrophy, Hereditary Polymorphous Posterior

Corneal Endothelial Dystrophy 1, Autosomal Dominant

Schlichting Dystrophy

Ched1

Corneal Endothelial Dystrophy 1, Autosomal Dominant, Formerly

Ched1, Formerly

Hereditary Polymorphus Posterior Corneal Dystrophy

Posterior Polymorphous Dystrophy

Hereditary Polymorphous Posterior Corneal Dystrophy

Dystrophy, Corneal, Posterior Polymorphous

Dystrophy, Corneal, Posterior Polymorphous, Type 1

Polymorphous Corneal Dystrophy

Corneal Endothelial Dystrophy 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-80013 THZ1 Inhibitor 99.84% Unkown
HY-103618 THZ531 Inhibitor 99.86% Unkown
HY-130250 SR-4835 Inhibitor 99.73% Unkown
HY-80013A THZ1 Hydrochloride Inhibitor 98.78% Unkown
HY-151110A PROTAC CDK12/13 Degrader-1 TFA Degrader 98.37% Unkown
HY-145072 BSJ-01-175 Inhibitor 99.45% Unkown
HY-151110 PROTAC CDK12/13 Degrader-1 Degrader / Unkown
HY-158170 CDK7-IN-28 Inhibitor / Unkown
HY-142696 CDK6/PIM1-IN-1 Inhibitor / Unkown
HY-150641 CDK-IN-9 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDK13 RGD RGD:1311226
Canis familiaris CDK13 VGNC VGNC:39045
Mus musculus CDK13 MGD MGI:1916812
Bos taurus CDK13 VGNC VGNC:27118
Macaca mulatta CDK13 VGNC VGNC:70966
Felis catus CDK13 VGNC VGNC:60695
Others CDK13 NCBI