CTSF - cathepsin F Gene

Homo sapiens

Also known as CATSF; CLN13

Gene ID: 8722 | Gene type: protein coding

About CTSF

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,563,464-66,568,606 (from NCBI)

This gene has 39 transcripts (splice variants), 541 orthologues, 12 paralogues and is associated with 2 phenotypes. Broad expression in ovary (RPKM 64.5), testis (RPKM 55.5) and 24 other tissues.

Summary

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the Cathepsin F precursor contains a C-terminal domain similar to the pro-segment of Cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The Cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine Protease Inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 Amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The Cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding Cathepsin W. [provided by RefSeq, Jul 2008]

CTSF Products(1)

mRNA	Protein	Name
NM_003793.4	NP_003784.2	cathepsin F precursor

CTSF Protein Structure

Inhibitor_I29

Peptidase_C1

0
100
200
300
400
484 a.a.

Protein Preferred Names

Protein Names

cathepsin F

Recombinant CTSF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71701	CTSF Protein, Human (His)	Q9UBX1 (273P-484D)	≥95%

Related Diseases

Diseases

Alias

Ceroid Lipofuscinosis, Neuronal, 13

Neuronal Ceroid Lipofuscinosis 13	CLN13
Neuronal Ceroid Lipofuscinosis 13 Kufs Type	Cln13 Disease
Lipofuscinosis, Ceroid, Neuronal, Type 13

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Ceroid Lipofuscinosis, Neuronal, 10

Neuronal Ceroid Lipofuscinosis Due To Cathepsin D Deficiency	Neuronal Ceroid Lipofuscinosis 10
CLN10	Cathepsin D Deficiency
Congenital Neuronal Ceroid Lipofuscinosis	Neuronal Ceroid Lipofuscinosis Cathepsin D-Deficient
Cln10 Disease	Ceroid Lipofuscinosis, Neuronal, Cathepsin D-Deficient
Cln10 Disease, Adult	Cln10 Disease, Congenital
Cln10 Disease, Juvenile	Cln10 Disease, Late Infantile
Ceroid Lipofuscinosis Neuronal Cathepsin D-Deficient	Cathepsin D Deficient Neuronal Ceroid Lipofuscinosis
Congenital Ncl	Lipofuscinosis, Ceroid, Neuronal, Type 10
Neuronal Ceroid Lipofuscinosis, Congenital

Ceroid Lipofuscinosis, Neuronal, 11

Neuronal Ceroid Lipofuscinosis 11	CLN11
Cln11 Disease	Grn-Related Neuronal Ceroid-Lipofuscinosis
Lipofuscinosis, Ceroid, Neuronal, Type 11

Spinocerebellar Ataxia, Autosomal Recessive 7

SCAR7	Autosomal Recessive Spinocerebellar Ataxia 7
Spinocerebellar Ataxia Autosomal Recessive 7	Childhood Onset Autosomal Recessive Slowly Progressive Spinocerebellar Ataxia
Childhood-Onset Autosomal Recessive Slowly Progressive Spinocerebellar Ataxia	Autosomal Recessive Spinocerebellar Ataxia Type 7
Spinocerebellar Ataxia, Autosomal Recessive, 7	Ataxia, Spinocerebellar, Autosomal Recessive, Type 7

Clonorchiasis

Oriental Liver Fluke Disease	Clonorchis Liver Infection
Clonorchiosis	Chinese Liver Fluke Disease
Hepatic Distomiasis Due To Clonorchis Sinensis	Infection Due To Clonorchis Sinensis
Hepatic Distomiasis	Hepatic Distomatosis
Chinese Liver Fluke Disorder	Oriental Liver Fluke Disorder
Clonorchis Infestation	Chinese Liver Fluke Infestation
Liver Fluke Disease Due To Clonorchis Sinensis	Oriental Liver Fluke Infestation

Progressive Myoclonus Epilepsy 3

Cln14 Disease	Epm3
Neuronal Ceroid Lipofuscinosis 14	Pme Type 3
Progressive Myoclonic Epilepsy Due To Kctd7 Deficiency	Progressive Myoclonus Epilepsy Type 3
Epilepsy, Progressive Myoclonic 3

Keratopathy

Paragonimiasis

Infection By Paragonimus	Lung Fluke Disease
Lung Fluke Infection	Pulmonary Paragonimiasis
Paragonimus Westermani Infection	Pulmonary Distomiasis
Parasitic Haemoptysis	Oriental Lung Fluke Disease
Endemic Haemoptysis	Paragonimosis
Pulmonary Distomatosis	Lung Fluke Disorder
Infestation By Paragonimus	Infection Due To Paragonimus Species
Infestation Due To Paragonimus Species	Oriental Lung Fluke Infestation
Endemic Oriental Haemoptysis

Ceroid Lipofuscinosis, Neuronal, 3

Batten Disease	Juvenile Neuronal Ceroid Lipofuscinosis
Neuronal Ceroid Lipofuscinosis 3	CLN3
Jncl	Spielmeyer-Vogt Disease
Vogt-Spielmeyer Disease	Spielmeyer-Sjogren Disease
Cln3 Disease	Neuronal Ceroid Lipofuscinosis, Juvenile
Cln3 Disease, Juvenile	Spielmeyer Sjogren Disease
Vogt Spielmeyer Disease	Batten-Mayou Disease
Batten-Spielmeyer-Vogt Disease	Cln3-Related Neuronal Ceroid-Lipofuscinosis
Juvenile Batten Disease	Juvenile Cerebroretinal Degeneration
Classic Juvenile Ncl	Classic Juvenile Neuronal Ceroid Lipofuscinosis
Juvenile Ncl	Lipofuscinosis, Ceroid, Neuronal, Type 3

Opisthorchiasis

Infection By Opisthorchis	Infection Due To Opisthorchis
Infection Due To Cat Liver Fluke	Infection By Cat Liver Fluke
Opisthorchiosis	Cat Liver Fluke Fever
Cat Liver Fluke Disease	Opisthorchis Infestation
Cat Liver Fluke Infestation

Spastic Paraplegia 48, Autosomal Recessive

SPG48	Hereditary Spastic Paraplegia 48
Autosomal Recessive Spastic Paraplegia Type 48	Autosomal Recessive Spastic Paraplegia 48
Paraplegia, Spastic, Type 48, Autosomal Recessive

Galactosialidosis

Goldberg Syndrome	Neuraminidase Deficiency With Beta-Galactosidase Deficiency
Ppca Deficiency	GSL
Lysosomal Protective Protein Deficiency	Cathepsin A Deficiency
Neuraminidase/Beta-Galactosidase Expression	Protective Protein/Cathepsin A Deficiency
Ngbe	Cathepsin A Deficiency Of
Lysosomal Protective Protein Deficiency Of	Deficiency Of Cathepsin A
Neuraminidase Beta-Galactosidase Deficiency	Protective Protein Cathepsin A Deficiency

Progressive Myoclonus Epilepsy

Pme	Progressive Myoclonic Epilepsy
Myoclonic Epilepsies, Progressive	Unverricht-Lundborg Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03334	CTSF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CTSF	MGD	MGI:1861434
Bos taurus	CTSF	VGNC	VGNC:27815
Macaca mulatta	CTSF	VGNC	VGNC:71555
Rattus norvegicus	CTSF	RGD	RGD:1308181
Canis familiaris	CTSF	VGNC	VGNC:39711
Felis catus	CTSF	VGNC	VGNC:82005
Others	CTSF	NCBI