2. Gene
  3. ADAM18 - ADAM metallopeptidase domain 18 Gene

ADAM18 - ADAM metallopeptidase domain 18 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ADAM27; tMDCIII

Gene ID: 8749 | Gene type: protein coding

About ADAM18

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:39,584,568-39,730,065 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 357 orthologues and 20 paralogues. Restricted expression toward testis (RPKM 6.7).

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

ADAM18 Products(3)

mRNA Protein Name
NM_001190956.2 NP_001177885.1 disintegrin and metalloproteinase domain-containing protein 18 isoform 2 precursor
NM_001320313.2 NP_001307242.1 disintegrin and metalloproteinase domain-containing protein 18 isoform 3 precursor
NM_014237.3 NP_055052.1 disintegrin and metalloproteinase domain-containing protein 18 isoform 1 preproprotein

ADAM18 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (29 - 141)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (184 - 379)

Disintegrin

Disintegrin: Disintegrin (399 - 476)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (479 - 589)

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  • 739 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 18

a disintegrin and metalloproteinase domain 18

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00274 ADAM18 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ADAM18 VGNC VGNC:55028
Macaca mulatta ADAM18 VGNC VGNC:83975
Rattus norvegicus ADAM18 RGD RGD:620405
Canis familiaris ADAM18 VGNC VGNC:49740
Mus musculus ADAM18 MGD MGI:105986
Others ADAM18 NCBI