CCNC - cyclin C Gene

Homo sapiens

Also known as CycC; SRB11; hSRB11

Gene ID: 892 | Gene type: protein coding

About CCNC

Cytogenetic location: 6q16.2 Genomic coordinates (GRCh38): 6:99,542,387-99,568,814 (from NCBI)

This gene has 19 transcripts (splice variants), 204 orthologues and is associated with 50 phenotypes. Ubiquitous expression in thyroid (RPKM 29.5), gall bladder (RPKM 20.6) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CCNC Products(3)

mRNA	Protein	Name
NM_001013399.2	NP_001013417.1	cyclin-C isoform b
NM_001363537.2	NP_001350466.1	cyclin-C isoform c
NM_005190.4	NP_005181.2	cyclin-C isoform a

CCNC Protein Structure

Cyclin_N

0
100
200
283 a.a.

Protein Preferred Names

Protein Names

cyclin-C

SRB11 homolog

Related Diseases

Diseases

Alias

Med23

Intellectual Disability, Autosomal Recessive 18

Autosomal Recessive Nonsyndromic Intellectual Disability-18

Developmental And Epileptic Encephalopathy 87

DEE87	Epileptic Encephalopathy, Early Infantile, 87
Eiee87	Developmental And Epileptic Encephalopathy, 87
Early Infantile Epileptic Encephalopathy 87

Opitz-Kaveggia Syndrome

Fg Syndrome	Fgs1
Fgs	Keller Syndrome
OKS	Fg Syndrome 1
Fg Syndrome Type 1	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum
Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum

Ohdo Syndrome

Young Simpson Syndrome	Ohdo Blepharophimosis Syndrome
Blepharophimosis Syndrome Ohdo Type	Blepharophimosis Intellectual Disability Syndromes
Bmrs	Blepharophimosis-Intellectual Disability Syndrome
Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth	Sbbys Syndrome
Say Barber Biesecker Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Bmrs, Ohdo Type	Blepharophimosis Syndrome, Ohdo Type
Ohdo-Madokoro-Sonoda Syndrome	Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type
Blepharophimosis - Intellectual Disability Syndrome

Breast Benign Neoplasm

Benign Tumour Of Breast

Benign Neoplasm Of Female Breast

Thoracic Benign Neoplasm

Benign Neoplasm Of Thorax

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia	ALL
Acute Lymphocytic Leukemia	Leukemia, Acute Lymphocytic, Susceptibility To, 1
Acute Lymphoblastic Leukaemia	Precursor Lymphoblastic Lymphoma/Leukemia
Precursor Lymphoid Neoplasm	Leukemia, Acute Lymphoblastic, Susceptibility To
B-Cell Acute Lymphoblastic Leukemia	Leukemia, Acute Lymphocytic 1
Acute Lymphocytic Leukaemia	Acute Lymphoblastic Leukemia/Lymphoma
All1	Childhood Acute Lymphoblastic Leukemia
Leukemia Acute Lymphoblastic 1	Leukemia Acute Lymphoblastic B-Hyperdiploid
Leukemia Acute Lymphocytic	Leukemia Acute Lymphocytic 1
Leukemia B-Cell Acute Lymphoblastic	Leukemia T-Cell Acute Lymphoblastic
Leukemia, Acute Lymphoblastic, 3	ALL3
Lymphoblastic Leukemia Acute	Leukemia, Acute, Lymphoblastic
Precursor Cell Lymphoblastic Leukemia Lymphoma	Leukemia, Lymphocytic, Acute, L1
Leukemia, Acute Lymphoblastic, Susceptibility To, 3

Uterine Benign Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02122	CCNC Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCNC	RGD	RGD:70905
Macaca mulatta	CCNC	VGNC	VGNC:70722
Mus musculus	CCNC	MGD	MGI:1858199
Bos taurus	CCNC	VGNC	VGNC:26961
Canis familiaris	CCNC	VGNC	VGNC:57219
Felis catus	CCNC	VGNC	VGNC:60554
Others	CCNC	NCBI