H1-10 - H1.10 linker histone Gene

Homo sapiens

Also known as H1X; H1FX; H1.10

Gene ID: 8971 | Gene type: protein coding

About H1-10

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:129,314,771-129,316,286 (from NCBI)

This gene has 2 transcripts (splice variants), 119 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

H1-10 Products(1)

mRNA	Protein	Name
NM_006026.4	NP_006017.1	histone H1.10

H1-10 Protein Structure

Linker_histone

0
100
200
213 a.a.

Protein Preferred Names

Protein Names

histone H1.10

H1 histone family member X

Related Diseases

Diseases

Alias

Animal Phobia

Zoophobia

Fear Of Animals

Epithelial-Stromal Tgfbi Dystrophy

Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05946	H1-10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	H1-10	VGNC	VGNC:109865
Rattus norvegicus	H1-10	RGD	RGD:1565596
Macaca mulatta	H1-10	VGNC	VGNC:109751
Mus musculus	H1-10	MGD	MGI:2685307
Bos taurus	H1-10	VGNC	VGNC:83614

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