2. Gene
  3. KLHL13 - kelch like family member 13 Gene

KLHL13 - kelch like family member 13 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BKLHD2

Gene ID: 90293 | Gene type: protein coding

About KLHL13

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:117,897,813-118,131,050 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 54 paralogues. Broad expression in endometrium (RPKM 9.9), kidney (RPKM 3.7) and 15 other tissues.

Summary

This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

KLHL13 Products(9)

mRNA Protein Name
NM_001168299.2 NP_001161771.1 kelch-like protein 13 isoform b
NM_001168300.2 NP_001161772.1 kelch-like protein 13 isoform c
NM_001168301.2 NP_001161773.1 kelch-like protein 13 isoform d
NM_001168302.2 NP_001161774.1 kelch-like protein 13 isoform d
NM_001168303.4 NP_001161775.2 kelch-like protein 13 isoform e
NM_001394863.1 NP_001381792.1 kelch-like protein 13 isoform a
NM_001394864.1 NP_001381793.1 kelch-like protein 13 isoform f
NM_001394866.1 NP_001381795.1 kelch-like protein 13 isoform g
NM_033495.4 NP_277030.2 kelch-like protein 13 isoform a

KLHL13 Protein Structure

BTB

BTB: BTB/POZ domain (82 - 188)

BACK

BACK: BTB And C-terminal Kelch (196 - 297)

Kelch_1

Kelch_1: Kelch motif (378 - 428)

Kelch_1

Kelch_1: Kelch motif (436 - 475)

Kelch_1

Kelch_1: Kelch motif (479 - 521)

Kelch_1

Kelch_1: Kelch motif (527 - 573)

Kelch_1

Kelch_1: Kelch motif (578 - 619)

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  • 655 a.a.
Protein Preferred Names Protein Names

kelch-like protein 13

BTB and kelch domain containing 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07357 KLHL13 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KLHL13 VGNC VGNC:63143
Mus musculus KLHL13 MGD MGI:1914705
Bos taurus KLHL13 VGNC VGNC:30643
Canis familiaris KLHL13 VGNC VGNC:42449
Rattus norvegicus KLHL13 RGD RGD:1559646
Macaca mulatta KLHL13 VGNC VGNC:74105